NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration

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dc.contributor.authorCabezas, Felipe
dc.contributor.authorCabello-Verrugio, Claudio
dc.contributor.authorGonzález, Natalia
dc.contributor.authorSalas, Jeremy
dc.contributor.authorRamírez, Manuel J.
dc.contributor.authorde la Vega, Eduardo
dc.contributor.authorOlguín, Hugo C
dc.date.accessioned2025-03-07T18:45:49Z
dc.date.available2025-03-07T18:45:49Z
dc.date.issued0023-12
dc.descriptionINDEXACION SCOPUS
dc.description.abstractBackground: Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanisms, including the ubiquitin–proteasome system, which is key for maintaining protein homeostasis. In this context, it has been shown that ubiquitin-ligase NEDD4-1 targets the transcription factor PAX7 for proteasome-dependent degradation, promoting muscle differentiation in vitro. Nonetheless, whether NEDD4-1 is required for satellite cell function in regenerating muscle remains to be determined. Results: Using conditional gene ablation, we show that NEDD4-1 loss, specifically in the satellite cell population, impairs muscle regeneration resulting in a significant reduction of whole-muscle size. At the cellular level, NEDD4-1-null muscle progenitors exhibit a significant decrease in the ability to proliferate and differentiate, contributing to the formation of myofibers with reduced diameter. Conclusions: These results indicate that NEDD4-1 expression is critical for proper muscle regeneration in vivo and suggest that it may control satellite cell function at multiple levels. © 2023, The Author(s).
dc.identifier.issn07169760
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63690
dc.language.isoen
dc.publisherBioMed Central Ltd
dc.subjectMuscle differentiation; Muscle stem cells; NEDD4-1; Satellite cells; Skeletal muscle regeneration
dc.titleNEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration
dc.typeArtículo
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