Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections
| dc.contributor.author | Vilos; Cristian | |
| dc.contributor.author | Constandil; Luis | |
| dc.contributor.author | Herrera, Natalia | |
| dc.contributor.author | Solar, Paula | |
| dc.contributor.author | Escobar-Fica, Jorge | |
| dc.contributor.author | Velásquez, Luis Alberto | |
| dc.date.accessioned | 2014-03-21T14:14:18Z | |
| dc.date.accessioned | 2016-05-31T17:45:55Z | |
| dc.date.available | 2014-03-21T14:14:18Z | |
| dc.date.available | 2016-05-31T17:45:55Z | |
| dc.date.issued | 2012 | |
| dc.description | Indexación: Web of Science; Scielo | |
| dc.description.abstract | Background: The infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics. The formulation of polymeric microparticles loaded with antibiotics for veterinary use can: reduce the number of required doses; protect the drug from inactivation; and maintain a sustained-release of the antibiotic drug at effective levels. Accomplishing all of these goals would have a significant economic and animal health impact on the livestock breeding industry. Results: In this work, we formulated ceftiofur-loaded PHBV microparticles (PHBV-CEF) with a spherical shape, a smooth surface and diameter sizes between 1.65 and 2.37 μm. The encapsulation efficiency was 39.5 ± 1.1% w/w, and we obtained a sustained release of ceftiofur in PBS-buffer (pH 7.4) over 7 days. The antibacterial activity of ceftiofur was preserved after the encapsulation procedure, and toxicity of PHBV-CEF microparticles evaluated by MTS was represented by an IC50 > 10 mg/mL. Conclusions: Our results suggest that PHBV-CEF particles have a potential application for improving the treatment of infectious diseases in the livestock breeding industry. Keywords: ceftiofur, drug delivery, livestock breeding industry, PHBV, polymeric microparticles | es |
| dc.identifier.citation | Electronic Journal of Biotechnology. Vol. 15. N° 4. Valparaíso, 2012. | es |
| dc.identifier.issn | 0717-3458 | |
| dc.identifier.other | DOI: 10.2225/vol15-issue4-fulltext-2 | |
| dc.identifier.uri | http://repositorio.unab.cl/xmlui/handle/ria/2422 | |
| dc.language.iso | en | es |
| dc.publisher | Pontificia Universidad Católica de Valparaíso | es |
| dc.subject | ceftiofur, drug delivery, livestock breeding industry, PHBV, polymeric microparticles | es |
| dc.title | Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections | es |
| dc.type | Artículo | es |
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