Genome sequencing and transcriptomic analysis of the Andean killifish Orestias ascotanensis reveals adaptation to high-altitude aquatic life

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dc.contributor.authorDi Genova, A.
dc.contributor.authorNardocci, G.
dc.contributor.authorMaldonado-Agurto, R.
dc.contributor.authorHodar, Ch.
dc.contributor.authorValdivieso, C.
dc.contributor.authorValdivieso, C.
dc.contributor.authorMorales, P.
dc.contributor.authorGajardo, F.
dc.contributor.authorMarina, R.
dc.contributor.authorGutiérrez, R.
dc.contributor.authorOrellana, A.
dc.contributor.authorCambiazo, V.
dc.contributor.authorCambiazo, V.
dc.contributor.authorGonzález, M.
dc.contributor.authorGlavic, A.
dc.contributor.authorMendez, M.
dc.contributor.authorMaass, A.
dc.contributor.authorAllende, M.
dc.contributor.authorMontecino, M.
dc.date.accessioned2024-09-11T12:54:27Z
dc.date.available2024-09-11T12:54:27Z
dc.date.issued2022-01
dc.descriptionTEXTO COMPLETO EN INGLÉS
dc.description.abstractOrestias ascotanensis (Cyprinodontidae) is a teleost pupfish endemic to springs feeding into the Ascotan saltpan in the Chilean Altiplano (3,700 m.a.s.l.) and represents an opportunity to study adaptations to high-altitude aquatic environments. We have de novo assembled the genome of O. ascotanensis at high coverage. Comparative analysis of the O. ascotanensis genome showed an overall process of contraction, including loss of genes related to G-protein signaling, chemotaxis and signal transduction, while there was expansion of gene families associated with microtubule-based movement and protein ubiquitination. We identified 818 genes under positive selection, many of which are involved in DNA repair. Additionally, we identified novel and conserved microRNAs expressed in O. ascotanensis and its closely-related species, Orestias gloriae. Our analysis suggests that positive selection and expansion of genes that preserve genome stability are a potential adaptive mechanism to cope with the increased solar UV radiation to which high-altitude animals are exposed to.
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0888754321004468
dc.identifier.citationGenomics, Volume 114, Issue 1 , January 2022, Pages 305-315
dc.identifier.doihttps://doi.org/10.1016/j.ygeno.2021.12.018
dc.identifier.issn1877-0509
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60067
dc.language.isoen
dc.publisherElsevier
dc.rights.licenseAttribution 4.0 International
dc.subjectOrestias ascotanensis
dc.subjectDNA repair
dc.subjectHigh-altitude
dc.subjectDesert pupfish
dc.subjectAltiplano
dc.subjectmicroRNAs
dc.titleGenome sequencing and transcriptomic analysis of the Andean killifish Orestias ascotanensis reveals adaptation to high-altitude aquatic life
dc.typeArtículo
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