Multiple levels of epigenetic control for bone biology and pathology

Vista sencilla de ítem
dc.contributor.authorMontecino, Martin
dc.contributor.authorStein, Gary
dc.contributor.authorStein, Janet
dc.contributor.authorZaidi, Kaleem
dc.contributor.authorAguilar, Rodrigo
dc.date.accessioned2023-07-03T15:15:59Z
dc.date.available2023-07-03T15:15:59Z
dc.date.issued2015-04
dc.descriptionIndexación: Scopuses
dc.description.abstractMultiple dimensions of epigenetic control contribute to regulation of gene expression that governs bone biology and pathology. Once confined to DNA methylation and a limited number of post-translational modifications of histone proteins, the definition of epigenetic mechanisms is expanding to include contributions of non-coding RNAs and mitotic bookmarking, a mechanism for retaining phenotype identity during cell proliferation. Together these different levels of epigenetic control of physiological processes and their perturbations that are associated with compromised gene expression during the onset and progression of disease, have contributed to an unprecedented understanding of the activities (operation) of the genomic landscape. Here, we address general concepts that explain the contribution of epigenetic control to the dynamic regulation of gene expression during eukaryotic transcription. This article is part of a Special Issue entitled Epigenetics and Bone. © 2015 Elsevier Inc. All rights reserved.es
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S8756328215000915?via%3Dihub
dc.identifier.citationBone Volume 81, Pages 733 - 738March 13, 2015es
dc.identifier.doi10.1016/j.bone.2015.03.013
dc.identifier.issn8756-3282
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51296
dc.language.isoenes
dc.publisherElsevier Inc.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectDNA methylationes
dc.subjectHistone modificationses
dc.subjectIntanuclear domainses
dc.subjectMitotic bookmarkinges
dc.subjectRUNX2 epigeneticses
dc.titleMultiple levels of epigenetic control for bone biology and pathologyes
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
ReciboSimpCL (4).pdf
Tamaño:
12.14 KB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista