A global metagenomic map of urban microbiomes and antimicrobial resistance

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dc.contributor.authorDanko, David
dc.contributor.authorBezdan, Daniela
dc.contributor.authorAfshin, Evan E.
dc.contributor.authorAhsanuddin, Sofia
dc.contributor.authorBhattacharya, Chandrima
dc.contributor.authorButler, Daniel J.
dc.contributor.authorChng, Kern Rei
dc.contributor.authorDonnellan, Daisy
dc.contributor.authorHecht, Jochen
dc.contributor.authorJackson, Katelyn
dc.contributor.authorKuchin, Katerina
dc.contributor.authorKarasikov, Mikhai
dc.date.accessioned2024-06-05T16:32:11Z
dc.date.available2024-06-05T16:32:11Z
dc.date.issued2021-06-24
dc.descriptionIndexación: Scopus.
dc.description.abstractWe present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.
dc.description.urihttps://linkinghub.elsevier.com/retrieve/pii/S0092867421005857
dc.identifier.citationCell Volume 184, Issue 13, Pages 3376 - 3393.e17 24 June 2021
dc.identifier.doi10.1016/j.cell.2021.05.002
dc.identifier.issn0092-8674
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/57340
dc.language.isoen_US
dc.publisherElsevier B.V.
dc.rights.licenseATRIBUCIÓN-NOCOMERCIAL-SINDERIVADAS 4.0 INTERNACIONAL
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subjectAMR
dc.subjectantimicrobial resistance
dc.subjectBGC
dc.subjectbuilt Environment
dc.subjectde novo assembly
dc.subjectglobal health
dc.subjectmetagenome
dc.subjectmicrobiome
dc.subjectNGS
dc.subjectshotgun sequencing
dc.titleA global metagenomic map of urban microbiomes and antimicrobial resistance
dc.typeArtículo
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