Transcription factor roles in the local adaptation to temperature in the Andean Spiny Toad Rhinella spinulosa

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dc.contributor.authorHinostroza, Fernando
dc.contributor.authorAraya-Duran, Ingrid
dc.contributor.authorPiñeiro, Alejandro
dc.contributor.authorLobos, Isabel
dc.contributor.authorPastenes, Luis
dc.date.accessioned2024-11-11T18:37:03Z
dc.date.available2024-11-11T18:37:03Z
dc.date.issued2024-12
dc.descriptionIndexación: Scopus.
dc.description.abstractEnvironmental temperature strongly influences the adaptation dynamics of amphibians, whose limited regulation capabilities render them susceptible to thermal oscillations. A central element of the adaptive strategies is the transcription factors (TFs), which act as master regulators that orchestrate stress responses, enabling species to navigate the fluctuations of their environment skillfully. Our study delves into the intricate relationship between TF expression and thermal adaptation mechanisms in the Rhinella spinulosa populations. We sought to elucidate the dynamic modulations of TF expression in prometamorphic and metamorphic tadpoles that inhabit two thermally contrasting environments (Catarpe and El Tatio Geyser, Chile) and which were exposed to two thermal treatments (25 °C vs. 20 °C). Our findings unravel an intriguing dichotomy in response strategies between these populations. First, results evidence the expression of 1374 transcription factors. Regarding the temperature shift, the Catarpe tadpoles show a multifaceted approach by up-regulating crucial TFs, including fosB, atf7, and the androgen receptor. These dynamic regulatory responses likely underpin the population’s ability to navigate thermal fluctuations effectively. In stark contrast, the El Tatio tadpoles exhibit a more targeted response, primarily up-regulating foxc1. This differential expression suggests a distinct focus on specific TFs to mitigate the effects of temperature variations. Our study contributes to understanding the molecular mechanisms governing thermal adaptation responses and highlights the resilience and adaptability of amphibians in the face of ever-changing environmental conditions. © The Author(s) 2024.
dc.description.urihttps://www-nature-com.recursosbiblioteca.unab.cl/articles/s41598-024-66127-5
dc.identifier.doi10.1038/s41598-024-66127-5
dc.identifier.issn20452322
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/61870
dc.language.isoen
dc.publisherScientific Reports, Volume 14, Issue 1 December 2024, Article number 15158
dc.rights.licenseAtribución/Reconocimiento 4.0 Internacional CC BY 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAcclimatization
dc.subjectAdaptation, Physiological
dc.subjectAnimals; Anura
dc.subjectBufonidae
dc.subjectChile
dc.subjectLarva
dc.subjectTemperature
dc.subjectTranscription Factors
dc.titleTranscription factor roles in the local adaptation to temperature in the Andean Spiny Toad Rhinella spinulosa
dc.typeArtículo
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TEXTO COMPLETO EN INGLÉS
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