Trichostatin a promotes the generation and suppressive functions of regulatory T cells
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Fecha
2013-05
Profesor/a Guía
Facultad/escuela
Idioma
en
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Título del volumen
Editor
Hindawi Limited
Nombre de Curso
Licencia CC
Attribution 3.0 Unported (CC BY 3.0)
Licencia CC
https://www.hindawi.com/journals/jir/2013/679804/#copyright
Resumen
Regulatory T cells are a specific subset of lymphocytes that suppress immune responses and play a crucial role in the maintenance of self-tolerance. They can be generated in the thymus as well as in the periphery through differentiation of naïve CD4+ T cells. The forkhead box P3 transcription factor (Foxp3) is a crucial molecule regulating the generation and function of Tregs. Here we show that the foxp3 gene promoter becomes hyperacetylated in in vitro differentiated Tregs compared to naïve CD4 + T cells. We also show that the histone deacetylase inhibitor TSA stimulated the in vitro differentiation of naïve CD4+ T cells into Tregs and that this induction was accompanied by a global increase in histone H3 acetylation. Importantly, we also demonstrated that Tregs generated in the presence of TSA have phenotypical and functional differences from the Tregs generated in the absence of TSA. Thus, TSA-generated Tregs showed increased suppressive activities, which could potentially be explained by a mechanism involving the ectonucleotidases CD39 and CD73. Our data show that TSA could potentially be used to enhance the differentiation and suppressive function of CD4+Foxp3+ Treg cells.
Notas
Indexación: Scopus.
Palabras clave
Histone Deacetylase Inhibitors, Valproic Acid, Animals
Citación
Clinical and Developmental Immunology, Volume 2013, 2013, Article number 679804
DOI
10.1155/2013/679804