Evaluation of ceftiofur-PHBV microparticles in rats

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dc.contributor.authorVilos, Cristian
dc.contributor.authorConstandil, Luis
dc.contributor.authorRodas, Paula I.
dc.contributor.authorCantin, Mario
dc.contributor.authorZepeda, Katherine
dc.contributor.authorHerrera, Natalia
dc.contributor.authorVelasquez, Luis A.
dc.date.accessioned2023-06-12T20:53:21Z
dc.date.available2023-06-12T20:53:21Z
dc.date.issued2014-05
dc.descriptionIndexación: Scopus.es
dc.description.abstractDespite the high number of antibiotics used for the treatment of infectious disease in animals, the development of slow release formulations presents a significant challenge, particu larly in using novel biomaterials with low cost. In this report, we studied the pharmacokinetics, toxicity, and therapeutic activity of ceftiofur–PHBV (ceftiofur–poly(3-hydroxybutyrate-co 3-hydroxyvalerate)) in rats. The pharmacokinetic study demonstrated a sustained release of ceftiofur into the bloodstream, with detectable levels over the minimum inhibitory concentration for at least 17 days after a single intramuscular injection of ceftiofur–PHBV (10 mg/kg weight). In addition, the toxicological evaluation of biochemical, hematological, and coagulation blood parameters at the therapeutic dose demonstrated the safety of ceftiofur–PHBV, with no adverse effects. In addition, ceftiofur–PHBV exhibited a therapeutic effect for a longer time period than the nonencapsulated ceftiofur in rats challenged with Salmonella Typhimurium. The slow release of ceftiofur from the ceftiofur–PHBV, its low toxicity in the blood parameters evaluated, and the efficacy in the rats infected with Salmonella Typhimurium make ceftiofur–PHBV a strong candidate for biotechnological applications in the veterinary industry.es
dc.description.urihttps://www.dovepress.com/evaluation-of-ceftiofurndashphbv-microparticles-in-rats-peer-reviewed-fulltext-article-DDDT
dc.identifier.citationDrug Design, Development and Therapy. Volume 8, Pages 651 - 666. 29 May 2014es
dc.identifier.doiDOI: 10.2147/DDDT.S60444
dc.identifier.issn1177-8881
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/50591
dc.language.isoenes
dc.publisherDove Medical Press Ltd.es
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectMicroparticleses
dc.subjectDrug Deliveryes
dc.subjectSalmonella Typhimuriumes
dc.subjectRat Infection Modeles
dc.subjectBlood Parameterses
dc.titleEvaluation of ceftiofur-PHBV microparticles in ratses
dc.typeArtículoes
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