Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy

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dc.contributor.authorFernandez, Ricardo
dc.contributor.authorNardocci, Gino
dc.contributor.authorNavarro, Cristina
dc.contributor.authorReyes, Edison P.
dc.contributor.authorAcuña-Castillo, Claudio
dc.contributor.authorCortes, Paula P.
dc.date.accessioned2023-07-03T22:05:18Z
dc.date.available2023-07-03T22:05:18Z
dc.date.issued2014
dc.descriptionIndexación: Scopus.es
dc.description.abstractSepsis progresses to multiple organ dysfunction due to the uncontrolled release of inflammatory mediators, and a growing body of evidence shows that neural signals play a significant role in modulating the immune response. Thus, similar toall other physiological systems, the immune system is both connected to and regulated by the central nervous system. The efferent arc consists of the activation of the hypothalamic–pituitary–adrenal axis, sympathetic activation, the cholinergic anti-inflammatory reflex, and the local release of physiological neuromodulators. Immunosensory activity is centered on the production of pro-inflammatory cytokines, signals that are conveyed to the brain through different pathways. The activation of peripheral sensory nerves, i.e., vagal paraganglia by the vagus nerve, and carotid body (CB) chemoreceptors by the carotid/sinus nerve are broadly discussed here. Despite cytokine receptor expression in vagal afferent fibers, pro-inflammatory cytokines have no significant effect on vagus nerve activity. Thus, the CB may be the source of immunosensory inputs and incoming neural signals and, in fact, sense inflammatory mediators, playing a protective role during sepsis. Considering that CB stimulation increases sympathetic activity and adrenal glucocorticoids release, the electrical stimulation of arterial chemoreceptors may be suitable therapeutic approach for regulating systemic inflammationes
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fphys.2014.00489/full
dc.identifier.citationFrontiers in Physiology. Volume 5, Issue DEC. 2014. Article number 489es
dc.identifier.doi10.3389/fphys.2014.00489
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51332
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.subjectSystemic Inflammationes
dc.subjectSepsises
dc.subjectReflex Control of Inflammationes
dc.subjectCarotid Bodyes
dc.subjectVagus Nervees
dc.titleNeural reflex regulation of systemic inflammation: potential new targets for sepsis therapyes
dc.typeArtículoes
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