A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections

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dc.contributor.authorCampanini-Salinas, J.
dc.contributor.authorAndrades-Lagos, J.
dc.contributor.authorGonzalez Rocha, G.
dc.contributor.authorChoquesillo-Lazarte, D.
dc.contributor.authorBollo Dragnic, S.
dc.contributor.authorFaúndez, M.
dc.contributor.authorAlarcón, P.
dc.contributor.authorSilva, F.
dc.contributor.authorVidal, R.
dc.contributor.authorSalas-Huenuleo, E.
dc.contributor.authorKogan, M.
dc.contributor.authorMella, J.
dc.contributor.authorRecabarren Gajardo, G.
dc.contributor.authorVásquez-Velásquez, D.
dc.date.accessioned2019-12-13T18:22:12Z
dc.date.available2019-12-13T18:22:12Z
dc.date.issued2018-07
dc.descriptionIndexación: Scopus.es
dc.description.abstractA rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class of compounds with antibacterial activity obtained by a simple, two step synthesis and screened the products for in vitro antibacterial activity against ATCC® strains using the broth microdilution method. The compounds exhibited minimum inhibitory concentrations (MIC) of 1⁻32 μg/mL against Gram-positive ATCC® strains. The structure⁻activity relationship indicated that the thiophenol ring is essential for antibacterial activity and the substituents on the thiophenol ring module, for antibacterial activity. The most promising compounds detected by screening were tested against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) clinical isolates. We found remarkable activity against VREF for compounds 7 and 16, were the MIC50/90 were 2/4 µg/mL and 4/4 µg/mL, respectively, while for vancomycin the MIC50/90 was 256/512 µg/mL. Neither compound affected cell viability in any of the mammalian cell lines at any of the concentrations tested. These in vitro data show that compounds 7 and 16 have an interesting potential to be developed as new antibacterial drugs against infections caused by VREF.es
dc.description.urihttps://www.mdpi.com/1420-3049/23/7/1776
dc.identifier.citationMolecules (Basel, Switzerland), 23(7).es
dc.identifier.issn1420-3049
dc.identifier.otherDOI: 10.3390/molecules23071776
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/11461
dc.language.isoenes
dc.publisherMDPI AGes
dc.subjectAntibacterial activityes
dc.subjectMethicillin-resistant Staphylococcus aureuses
dc.subjectQuinonic-antibioticses
dc.subjectVancomycin-resistant Enterococcus faeciumes
dc.titleA New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infectionses
dc.typeArtículoes
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