A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

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dc.contributor.authorCruces, Pablo
dc.contributor.authorRetamal, Jaime
dc.contributor.authorHurtado, Daniel E.
dc.contributor.authorErranz, Benjamín
dc.contributor.authorIturrieta, Pablo
dc.contributor.authorGonzález, Carlos
dc.contributor.authorDíaz, Franco
dc.date.accessioned2022-06-15T17:12:02Z
dc.date.available2022-06-15T17:12:02Z
dc.date.issued2020-08
dc.descriptionIndexación: Scopus.es
dc.description.abstractDeterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view. © 2020 The Author(s).es
dc.description.urihttps://ccforum.biomedcentral.com/articles/10.1186/s13054-020-03197-7
dc.identifier.citationCritical Care Open Access Volume 24, Issue 110 August 2020 Article number 494es
dc.identifier.doi10.1186/s13054-020-03197-7
dc.identifier.issn13648535
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/22846
dc.language.isoenes
dc.publisherBioMed Central Ltdes
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCOVID-19es
dc.subjectLung straines
dc.subjectMechanical ventilationes
dc.subjectP-SILIes
dc.subjectSARS-CoV2es
dc.subjectWork of breathinges
dc.titleA physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infectiones
dc.typeArtículoes
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