Modified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae

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dc.contributor.authorRodas, Paula I.
dc.contributor.authorJauffret, Claudia
dc.contributor.authorPérez, Doris
dc.contributor.authorGonzález, Yaquelin
dc.contributor.authorCarreño, Carolina
dc.contributor.authorTapia, Cecilia V.
dc.contributor.authorOsorio, Eduardo
dc.contributor.authorVelasquez, Luis A.
dc.contributor.authorChristodoulides, Myron
dc.date.accessioned2024-09-17T16:23:36Z
dc.date.available2024-09-17T16:23:36Z
dc.date.issued2017
dc.descriptionIndexación: Scopus
dc.description.abstractEpithelial shedding and scarring of fallopian tube mucosa are the main consequences of sexually transmitted Neisseria gonorrhoeae infection and probably involve an imbalance of host extracellular matrix components and their regulators such as matrix metalloproteinases (MMPs). In the current study, primary human fallopian tube epithelial cells were infected with N. gonorrhoeae, and MMP patterns were examined. Gonococcal infection induced a significant increase in secreted MMP-9 and an accumulation of cytoplasmic MMP-2 over time, but no significant MMP-3 or MMP-8 production was observed. Thus, MMP-9 in particular could play a role in tubal scarring in response to gonococcal infection. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society.
dc.description.urihttps://academic-oup-com.recursosbiblioteca.unab.cl/jid/article/215/3/452/2632219
dc.identifier.citationJournal of Infectious Diseases Volume 215, Issue 3, Pages 452 - 4552017
dc.identifier.doi10.1093/infdis/jiw568
dc.identifier.issn0022-1899
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60262
dc.language.isoen
dc.publisherOxford University Press
dc.rights.licenseAtribución/Reconocimiento 4.0 Internacional CC BY 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectExtracellular matrix
dc.subjectHuman Fallopian tube epithelial cells
dc.subjectMatrix metalloproteinases
dc.subjectNeisseria gonorrhoeae
dc.titleModified profile of matrix metalloproteinase 2 and 9 production by human fallopian tube epithelial cells after infection in vitro with neisseria gonorrhoeae
dc.typeArtículo
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