The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

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dc.contributor.authorSalazar, Javier
dc.contributor.authorCarmona, Thais
dc.contributor.authorZacconi, Flavia C.
dc.contributor.authorVenegas-Yazigi, Diego
dc.contributor.authorCabello-Verrugio, Claudio
dc.contributor.authorIl Choi, Won
dc.contributor.authorVilos, Cristian
dc.date.accessioned2025-03-11T13:42:39Z
dc.date.available2025-03-11T13:42:39Z
dc.date.issued2023-01
dc.descriptionIndexación: Scopus
dc.description.abstractSkin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments. © 2022 by the authors.
dc.description.urihttps://www.mdpi.com/1999-4923/15/1/10
dc.identifier.citationPharmaceutics. Volume 15, Issue 1. January 2023. Article number 10
dc.identifier.doi10.3390/pharmaceutics15010010
dc.identifier.issn1999-4923
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63730
dc.language.isoen
dc.publisherMDPI
dc.rights.licenseAttribution 4.0 International Deed (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectDermis
dc.subjectDrug Delivery
dc.subjectMetal-organic Frameworks (MOFs)
dc.subjectNanoparticles
dc.subjectSkin
dc.titleThe Human Dermis as a Target of Nanoparticles for Treating Skin Conditions
dc.typeArtículo
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