A single clonal lineage of transmissible cancer identified in two marine mussel species in South America and Europe
Cargando...
Archivos
Fecha
2019-11
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
eLife Sciences Publications Ltd
Nombre de Curso
Licencia CC
Atribución 4.0 Internacional (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Transmissible cancers, in which cancer cells themselves act as an infectious agent, have been identified in Tasmanian devils, dogs, and four bivalves. We investigated a disseminated neoplasia affecting geographically distant populations of two species of mussels (Mytilus chilensis in South America and M. edulis in Europe). Sequencing alleles from four loci (two nuclear and two mitochondrial) provided evidence of transmissible cancer in both species. Phylogenetic analysis of cancer-associated alleles and analysis of diagnostic SNPs showed that cancers in both species likely arose in a third species of mussel (M. trossulus), but these cancer cells are independent from the previously identified transmissible cancer in M. trossulus from Canada. Unexpectedly, cancers from M. chilensis and M. edulis are nearly identical, showing that the same cancer lineage affects both. Thus, a single transmissible cancer lineage has crossed into two new host species and has been transferred across the Atlantic and Pacific Oceans and between the Northern and Southern hemispheres. © 2019, eLife Sciences Publications Ltd. All rights reserved.
Notas
Indexación: Scopus
Palabras clave
Alleles, Animals, Aquatic Organisms, Europe, Mytilus, Neoplasms, Phylogeny, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, South America
Citación
eLife Volume 8November 2019 Article number e47788
DOI
10.7554/eLife.47788