Heme oxygenase-1 as a modulator of intestinal inflammation development and progression

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dc.contributor.authorSebastián, V.P.
dc.contributor.authorSalazar, G.A.
dc.contributor.authorCoronado-Arrázola, I.
dc.contributor.authorSchultz, B.M.
dc.contributor.authorVallejos, O.P.
dc.contributor.authorBerkowitz, L.
dc.contributor.authorÁlvarez-Lobos, M.M.
dc.contributor.authorRiedel, C.A.
dc.contributor.authorKalergis, A.M.
dc.contributor.authorBueno, S.M.
dc.date.accessioned2019-12-04T14:13:50Z
dc.date.available2019-12-04T14:13:50Z
dc.date.issued2018-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractHeme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the heme group contained in several important proteins, such as hemoglobin, myoglobin, and cytochrome p450. The enzymatic reaction catalyzed by HMOX1 generates Fe2+, biliverdin and CO. It has been shown that HMOX1 activity and the by-product CO can downmodulate the damaging immune response in several models of intestinal inflammation as a result of pharmacological induction of HMOX1 expression and the administration of non-toxic amounts of CO. Inflammatory Bowel Diseases, which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), are one of the most studied ailments associated to HMOX1 effects. However, microbiota imbalances and infections are also important factors influencing the occurrence of acute and chronic intestinal inflammation, where HMOX1 activity may play a major role. As part of this article we discuss the immune modulatory capacity of HMOX1 during IBD, as well during the infections and interactions with the microbiota that contribute to this inflammatory disease. © 2018 Sebastián, Salazar, Coronado-Arrázola, Schultz, Vallejos, Berkowitz, álvarez-Lobos, Riedel, Kalergis and Bueno.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.01956/full
dc.identifier.citationFrontiers in Immunology, 9(SEP), art. no. 1956.es
dc.identifier.issn1664-3224
dc.identifier.otherDOI: 10.3389/fimmu.2018.01956
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/11080
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.subjectCarbon monoxidees
dc.subjectColorectal canceres
dc.subjectHeme oxygenase-1es
dc.subjectInfectiones
dc.subjectInflammationes
dc.subjectInflammatory bowel diseasees
dc.subjectMicrobiotaes
dc.subjectNuclear factor erythroid 2-related factor 2es
dc.titleHeme oxygenase-1 as a modulator of intestinal inflammation development and progressiones
dc.typeArtículoes
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