In vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivo

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dc.contributor.authorFlores-Santibáñez, F.
dc.contributor.authorCuadra, B.
dc.contributor.authorFernández, D.
dc.contributor.authorRosemblatt, M.V.
dc.contributor.authorNúñez, S.
dc.contributor.authorCruz, P.
dc.contributor.authorGálvez-Cancino, F.
dc.contributor.authorCésar Cárdenas, J.
dc.contributor.authorLladser, A.
dc.contributor.authorRosemblatt, M.
dc.contributor.authorBono, M.R.
dc.contributor.authorSauma, D.
dc.date.accessioned2018-08-21T15:27:27Z
dc.date.available2018-08-21T15:27:27Z
dc.date.issued2018-02
dc.descriptionIndexación: Scopus.es_ES
dc.description.abstractMemory CD8+ T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8+ T cell effector subsets to persist and become memory cells has not been fully characterized. Type 1 CD8+ T (Tc1) cells produce interferon-γ and are endowed with high cytotoxic capacity, whereas IL-17-producing CD8+ T (Tc17) cells are less cytotoxic but display enhanced self-renewal capacity. We sought to evaluate the functional properties of in vitro-generated Tc17 cells and elucidate their potential to become long lasting memory cells. Our results show that in vitro-generated Tc17 cells display a greater in vivo persistence and expansion in response to secondary antigen stimulation compared to Tc1 cells. When transferred into recipient mice, Tc17 cells persist in secondary lymphoid organs, present a recirculation behavior consistent with central memory T cells, and can shift to a Tc1 phenotype. Accordingly, Tc17 cells are endowed with a higher mitochondrial spare respiratory capacity than Tc1 cells and express higher levels of memory-related molecules than Tc1 cells. Together, these results demonstrate that in vitro-generated Tc17 cells acquire a central memory program and provide a lasting reservoir of Tc1 cells in vivo, thus supporting the use of Tc17 lymphocytes in the design of novel and more effective therapies.es_ES
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.00209/full
dc.identifier.citationFrontiers in Immunology, 9(FEB), art. no. 209.es_ES
dc.identifier.issn1664-3224
dc.identifier.otherDOI: 10.3389/fimmu.2018.00209
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/6727
dc.language.isoenes_ES
dc.publisherFrontiers Mediaes_ES
dc.subjectCD8+ T cell memoryes_ES
dc.subjectHominges_ES
dc.subjectOxidative metabolismes_ES
dc.subjectPersistencees_ES
dc.subjectSecondary expansiones_ES
dc.subjectTc17 cellses_ES
dc.titleIn vitro-generated Tc17 cells present a memory phenotype and serve as a reservoir of Tc1 cells in vivoes_ES
dc.typeArtículoes_ES
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