Immune evasion by herpes simplex virus

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dc.contributor.authorRetamal-Díaz, Angello R.
dc.contributor.authorSuazo, Paula A.
dc.contributor.authorGarrido, Ignacio
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorGonzález, Pablo A.
dc.date.accessioned2023-07-13T16:20:04Z
dc.date.available2023-07-13T16:20:04Z
dc.date.issued2015-02
dc.descriptionIndexación: Scopuses
dc.description.abstractHerpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination. © 2015, Sociedad Chilena de Infectologia. All rights reserved.es
dc.description.urihttps://www-scielo-cl.recursosbiblioteca.unab.cl/scielo.php?script=sci_arttext&pid=S0716-10182015000200009&lng=en&nrm=iso&tlng=en
dc.identifier.citationRevista Chilena de Infectologia Volume 32, Issue 1, Pages 58 - 70February 2015es
dc.identifier.doi10.4067/S0716-10182015000200009
dc.identifier.issn0716-1018
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51634
dc.language.isoenes
dc.publisherSociedad Chilena de Infectologiaes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAdaptive immune evasiones
dc.subjectGenital infectiones
dc.subjectInnate immune evasiones
dc.subjectLatencyes
dc.subjectReactivationes
dc.titleImmune evasion by herpes simplex viruses
dc.title.alternativeEvasión de la respuesta inmune por virus herpes simplexes
dc.title.alternativeEvasión de la respuesta inmune por virus herpes simplexes
dc.typeArtículoes
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