What do we really know about 5-HT1A receptor signaling in neuronal cells?
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Fecha
2016-11
Autores
Profesor/a Guía
Facultad/escuela
Idioma
en
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Frontiers Media S.A.
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Licencia CC
Atribution 4.0 International (CC BY 4.0)
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https://creativecommons.org/licenses/by/4.0/deed.es y
Resumen
Serotonin (5-HT) is a neurotransmitter that plays an important role in neuronal plasticity.
Variations in the levels of 5-HT at the synaptic cleft, expression or dysfunction of
5-HT receptors may alter brain development and predispose to various mental diseases.
Here, we review the transduction pathways described in various cell types transfected
with recombinant 5-HT1A receptor (5-HT1AR), specially contrasting with those findings
obtained in neuronal cells. The 5-HT1AR is detected in early stages of neural development
and is located in the soma, dendrites and spines of hippocampal neurons. The 5-HT1AR
differs from other 5-HT receptors because it is coupled to different pathways, depending
on the targeted cell. The signaling pathway associated with this receptor is determined
by Gα isoforms and some cascades involve βγ signaling. The activity of 5-HT1AR usually
promotes a reduction in neuronal excitability and firing, provokes a variation in cAMP
and Ca2+, levels which may be linked to specific types of behavior and cognition.
Furthermore, evidence indicates that 5-HT1AR induces neuritogesis and synapse
formation, probably by modulation of the neuronal cytoskeleton through MAPK and
phosphoinositide-3-kinase (PI3K)-Akt signaling pathways. Advances in understanding
the actions of 5-HT1AR and its association with different signaling pathways in the central
nervous system will reveal their pivotal role in health and disease.
Notas
Indexación: Scopus.
Palabras clave
Serotonin, 5HT1AR, Signaling, CHO, Neurons, ERK, AKT, Cytoskeleton
Citación
Frontiers in Cellular Neuroscience. Volume 10, Issue NOV2016. 24 November 2016. Article number 272
DOI
10.3389/fncel.2016.00272