Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico

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dc.contributor.authorBruna, Flavia
dc.contributor.authorFernández, Katia
dc.contributor.authorUrrejola, Felipe
dc.contributor.authorTouma, Jorge
dc.contributor.authorNavarro, Myriam
dc.contributor.authorSepúlveda, Betsabet
dc.contributor.authorLarrazabal Fuentes, María
dc.contributor.authorParedes, Adrián
dc.contributor.authorNeira, Iván
dc.contributor.authorFerrando, Matías
dc.contributor.authorOsorio, Manuel
dc.contributor.authorYáñez, Osvaldo
dc.contributor.authorBravo, Jessica
dc.date.accessioned2023-04-11T21:24:37Z
dc.date.available2023-04-11T21:24:37Z
dc.date.issued2022-12
dc.descriptionIndexación: Scopus.es
dc.description.abstractChilean Laureliopsis philippiana has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, Laureliopsis philippiana leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. In vitro antioxidant potential was analyzed, and antitumor activity was evaluated in non-tumor and tumor cell culture lines. Caenorhabditis elegans was used as a model for evaluating toxicity, and the chemical composition of the essential oil was analyzed using gas chromatography–mass spectrometry. The oil contains six major monoterpenes: eucalyptol (27.7 %), linalool (27.6 %), isozaphrol (19.5 %), isohomogenol (12.6 %), α-terpineol (7.7 %), and eudesmol (4.8 %). Based on quantum mechanical calculations, isosafrole and isohomogenol conferred in vitro antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical Helicobacter pylori isolates (MIC 64 and MBC > 128 μg·mL−1), Staphylococcus aureus (MIC 32 and MBC > 64 μg·mL−1), Escherichia coli (MIC 8 and MBC 16 μg·mL−1) and Candida albicans (MIC 64 and > 128 μg·mL−1). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against Caenorhabditis elegans (0.39 to 1.56 μg·mL−1). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation. © 2022 The Authorses
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S1878535222005871?via%3Dihub
dc.identifier.citationArabian Journal of Chemistry, Volume 15, Issue 12December 2022 Article number 104271es
dc.identifier.doi10.1016/j.arabjc.2022.104271
dc.identifier.issn1878-5352
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48448
dc.language.isoenes
dc.publisherElsevier B.V.es
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAntimicrobial activityes
dc.subjectAntioxidantes
dc.subjectAntiproliferativees
dc.subjectChemical compositiones
dc.subjectEssential oiles
dc.subjectLaureliopsis philippianaes
dc.titleChemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silicoes
dc.typeArtículoes
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