Mesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling

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dc.contributor.authorSajadian, Seyed Ali
dc.contributor.authorEsfandiari, Nadia
dc.contributor.authorRojas, Adrián
dc.contributor.authorHemmati, Salar
dc.contributor.authorJouyban, Abolghasem
dc.contributor.authorAguila, Gonzalo
dc.contributor.authorGarlapati, Chandrasekhar
dc.date.accessioned2025-03-07T15:18:06Z
dc.date.available2025-03-07T15:18:06Z
dc.date.issued0025-12
dc.descriptionINDEXACION SCOPUS
dc.description.abstractIn this study, the solubility of mesalazine in supercritical carbon dioxide with and without cosolvent was carried out for the first time at different temperatures and pressure values ranging from 308 to 338 K and 12 to 30 MPa, respectively. The determined experimental molar solubilities of mesalazine in supercritical carbon dioxide were in the range of 4.41 × 10–5 to 9.97 × 10–5 (308 K), 3.9 × 10–5 to 13.1 × 10–5 (318 K), 3.4 × 10–5 to 16 × 10–5 (328 K) and 3.3 × 10–5 to 18.4 × 10–5 (338 K). Meanwhile, the determined experimental molar solubilities in supercritical carbon dioxide using 2% dimethyl sulfoxide as cosolvent were in the range of 28.22 × 10–5 to 36.2 × 10–5 (308 K), 26.07 × 10–5 to 51.41 × 10–5 (318 K), 25.02 × 10–5 to 69.07 × 10–5 (328 K) and 25.86 × 10–5 to 82.6 × 10–5 (338 K). A novel association model was employed to simulate the solubility data of the binary and ternary systems. Various semiempirical correlations were utilized to calculate the solubility of mesalazine in supercritical carbon dioxide. The new association model was deemed the most superior model, achieving an average absolute relative deviation value of 4.13% without a cosolvent, and 3.36% when a cosolvent was included. © The Author(s) 2025.
dc.identifier.doi10.1038/s41598-025-86004-z
dc.identifier.issn20452322
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63682
dc.language.isoen
dc.publisherNature Research
dc.rights.licenseCC BY LICENSE
dc.subjectCosolvent; Density models; Mesalazine; New association model; Solubility; Supercritical carbon dioxide
dc.titleMesalazine solubility in supercritical carbon dioxide with and without cosolvent and modeling
dc.typeArtículo
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