Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response

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dc.contributor.authorSauma, Daniela
dc.contributor.authorCrisóstomo, Natalia
dc.contributor.authorFuentes, Camila
dc.contributor.authorGleisner, María Alejandra
dc.contributor.authorHidalgo, Yessia
dc.contributor.authorFuenzalida, María José
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorBono, María Rosa
dc.date.accessioned2024-04-22T12:59:00Z
dc.date.available2024-04-22T12:59:00Z
dc.date.issued2017-08
dc.descriptionIndexación: Scopus
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased autoantibody production that leads to multiple tissue injuries. Dendritic cells (DCs) are important orchestrators of immune responses and key components in fine-tuning the balance between tolerance and immunity. However, their role in autoimmune disorders such as SLE remains uncertain. We analyzed the contribution of DCs in triggering SLE by adoptively transferring splenic DCs from aged autoimmune [NZB×NZW]F1 (BWF1) mice to young healthy BWF1 mice. We observed that the transfer of DCs from autoimmune mice to pre-autoimmune mice induced high autoantibody titers in the serum of recipient mice. Moreover, autoimmune DCs from aged BWF1 mice were crucial for the expansion and differentiation of plasmablasts and CD5+ B cells or B1-like cells in the peripheral blood, and spleen of recipient BWF1 mice, a phenomenon that is observed in autoimmune BWF1 mice. On the other hand, DCs from aged BWF1 mice participated in the expansion and differentiation of DCs and IFN-γ-producing T cells. These results reveal that DCs from autoimmune BWF1 mice exhibit functional and phenotypic characteristics that allow them to trigger B cell hyperactivation, as well as DC and T cell expansion and differentiation, thereby promoting an exacerbated humoral response in lupus-prone mice. © 2017, The Author(s).
dc.identifier.citationImmunologic Research Volume 65, Issue 4, Pages 957 - 9681 August 2017
dc.identifier.issn0257-277X
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56218
dc.language.isoen
dc.publisherHumana Press Inc.
dc.rights.licenseCC BY 4.0 DEED Atribución 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAutoimmunity
dc.subjectB lymphocytes
dc.subjectDendritic cells
dc.subjectHumoral response
dc.subjectSystemic lupus erythematosus
dc.titleAdoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral response
dc.typeArtículo
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