Arabidopsis RAD23B regulates pollen development by mediating degradation of KRP1

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dc.contributor.authorLi, Lan
dc.contributor.authorLi, Bin
dc.contributor.authorXie, Chong
dc.contributor.authorZhang, Teng
dc.contributor.authorBorassi, Cecilia
dc.contributor.authorEstevez, José M.
dc.contributor.authorLi, Xiushan
dc.contributor.authorLiu, Xuanming
dc.date.accessioned2023-12-04T15:10:18Z
dc.date.available2023-12-04T15:10:18Z
dc.date.issued2020-07-06
dc.descriptionIndexación Scopuses
dc.description.abstractThe ubiquitin (Ub)/26S proteasome system (UPS) plays a key role in plant growth, development, and survival by directing the turnover of numerous regulatory proteins. In the UPS, the ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains function as hubs for ubiquitin-mediated protein degradation. Radiation sensitive 23 (RAD23), which has been identified as a UBL/UBA protein, contributes to the progression of the cell cycle, stress responses, ER proteolysis, and DNA repair. Here, we report that pollen development is arrested at the microspore stage in a rad23b null mutant. We demonstrate that RAD23B can directly interact with KIP-related protein 1 (KRP1) through its UBL-UBA domains. In addition, plants overexpressing KRP1 have defects in pollen development, which is a phenotype similar to the rad23b mutant. RAD23B promotes the degradation of KRP1 in vivo, which is accumulated following treatment with the proteasome inhibitor MG132. Our results indicate that RAD23B plays an important in pollen development by controlling the turnover of the key cell cycle protein, KRP1.es
dc.identifier.citationJournal of Experimental Botany Volume 71, Issue 14, Pages 4010 - 4019 6 July 2020es
dc.identifier.doi10.1093/jxb/eraa167en
dc.identifier.issn0022-0957
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/54367
dc.language.isoenes
dc.publisherOxford University Presses
dc.rights.licenseCC BY 4.0 DEED Atribución 4.0 Internacionalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.esen
dc.subjectCell cyclees
dc.subjectKRP1es
dc.subjectPollen abortiones
dc.subjectProteasome systemes
dc.subjectRAD23Bes
dc.subjectUbiquitines
dc.titleArabidopsis RAD23B regulates pollen development by mediating degradation of KRP1es
dc.typeArtículoes
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