Weighted gene co-expression network analysis reveals immune evasion related genes in Echinococcus granulosus sensu stricto

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dc.contributor.authorPereira, Ismael
dc.contributor.authorPrado Paludo, Gabriela
dc.contributor.authorHidalgo, Christian
dc.contributor.authorStoore, Caroll
dc.contributor.authorBaquedano, María Soledad
dc.contributor.authorCabezas, Carolina
dc.contributor.authorCancela, Martín
dc.contributor.authorFerreira, Henrique Bunselmeyer
dc.contributor.authorBastías, Macarena
dc.contributor.authorRiveros, Aníbal
dc.contributor.authorMeneses, Claudio
dc.contributor.authorSáenz, Leonardo
dc.contributor.authorParedes, Rodolfo
dc.date.accessioned2025-03-28T20:06:33Z
dc.date.available2025-03-28T20:06:33Z
dc.date.issued2023
dc.descriptionIndexación: Scopus
dc.descriptionThis study was approved by the Universidad Andres Bello bioethics committee, Protocol Number 012/2019. Funding The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Agencia Nacional de Investigación y Desarrollo (ANID) (FONDECYT grant number 1231620).
dc.description.abstractCystic echinococcosis (CE) is a zoonotic disease caused by the tapeworm Echinococcus granulosus sensu lato (s.l). In the intermediate host, this disease is characterized by the growth of cysts in viscera such as liver and lungs, inside of which the parasite develops to the next infective stage known as protoscoleces. There are records that the infected viscera affect the development and morphology of E. granulosus s.l. protoscolex in hosts such as buffalo or humans. However, the molecular mechanisms that drive these differences remains unknown. Weighted gene co-expression network analysis (WGCNA) using a set of RNAseq data obtained from E. granulosus sensu stricto (s.s.) protoscoleces found in liver and lung cysts reveals 34 modules in protoscoleces of liver origin, of which 12 have differential co-expression from protoscoleces of lung origin. Three of these twelve modules contain hub genes related to immune evasion: tegument antigen, tegumental protein, ubiquitin hydrolase isozyme L3, COP9 signalosome complex subunit 3, tetraspanin CD9 antigen, and the methyl-CpG-binding protein Mbd2. Also, two of the twelve modules contain only hypothetical proteins with unknown orthology, which means that there are a group of unknown function proteins co-expressed inside the protoscolex of liver CE cyst origin. This is the first evidence of gene expression differences in protoscoleces from CE cysts found in different viscera, with co-expression networks that are exclusive to protoscoleces from liver CE cyst samples. This should be considered in the control strategies of CE, as intermediate hosts can harbor CE cysts in liver, lungs, or both organs simultaneously. Copyright © 2024 Pereira, Paludo, Hidalgo, Stoore, Baquedano, Cabezas, Cancela, Ferreira, Bastías, Riveros, Meneses, Sáenz and Paredes.
dc.description.urihttps://www.ebm-journal.org/journals/experimental-biology-and-medicine/articles/10.3389/ebm.2024.10126/full
dc.identifier.citationExperimental Biology and Medicine. Volume 249. 2023. Article number 10126
dc.identifier.doi10.3389/ebm.2024.10126
dc.identifier.issn1535-3702
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/63906
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rights.licenseAttribution 4.0 International Deed (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCo-expression network
dc.subjectCystic Echinococcosis
dc.subjectEchinococcus Granulosus
dc.subjectRNAseq
dc.subjectWGCNA
dc.titleWeighted gene co-expression network analysis reveals immune evasion related genes in Echinococcus granulosus sensu stricto
dc.typeArtículo
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