Modulation of immunity and inflammation by the Mineralocorticoid receptor and Aldosterone

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dc.contributor.authorMuñoz-Durango, N.
dc.contributor.authorVecchiola, A.
dc.contributor.authorGonzalez-Gomez, L.M.
dc.contributor.authorSimon, F.
dc.contributor.authorRiedel, C.A.
dc.contributor.authorFardella, C.E.
dc.contributor.authorKalergis, A.M.
dc.date.accessioned2023-08-28T16:28:56Z
dc.date.available2023-08-28T16:28:56Z
dc.date.issued2015
dc.descriptionIndexación: Scopuses
dc.description.abstractThe mineralocorticoid receptor (MR) is a ligand dependent transcription factor. MR has been traditionally associated with the control of water and electrolyte homeostasis in order to keep blood pressure through aldosterone activation. However, there is growing evidence indicating that MR expression is not restricted to vascular and renal tissues, as it can be also expressed by cells of the immune system, where it responds to stimulation or antagonism, controlling immune cell function. On the other hand, aldosterone also has been associated with proinflammatory immune effects, such as the release of proinflammatory cytokines, generating oxidative stress and inducing fibrosis. The inflammatory participation of MR and aldosterone in the cardiovascular disease suggests an association with alterations in the immune system. Hypertensive patients show higher levels of proinflammatory mediators that can be modulated by MR antagonism. Although these proinflammatory properties have been observed in other autoimmune and chronic inflammatory diseases, the cellular and molecular mechanisms that mediate these effects remain unknown. Here we review and discuss the scientific work aimed at determining the immunological role of MR and aldosterone in humans, as well as animal models. © 2015 N. Muñoz-Durango et al.es
dc.description.urihttps://www.hindawi.com/journals/bmri/2015/652738/
dc.identifier.citationBioMed Research International Volume 20152015 Article number 652738es
dc.identifier.doi10.1155/2015/652738
dc.identifier.issn2314-6133
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52865
dc.language.isoenes
dc.publisherHindawi Publishing Corporationes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.titleModulation of immunity and inflammation by the Mineralocorticoid receptor and Aldosteronees
dc.typeArtículoes
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