Intensive care unit-acquired weakness: a review from molecular mechanisms to its impact in COVID-2019

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dc.contributor.authorGonzález, Andrea
dc.contributor.authorAbrigo, Johanna
dc.contributor.authorAchiardi, Oscar
dc.contributor.authorSimon, Felipe
dc.contributor.authorCabello-Verrugio, Claudio
dc.date.accessioned2023-05-09T19:25:54Z
dc.date.available2023-05-09T19:25:54Z
dc.date.issued2022-09
dc.descriptionIndexación: Scopus.es
dc.description.abstractIntensive Care Unit-Acquired Weakness (ICU-AW) is a generalized and symmetric neuromuscular dysfunction associated with critical illness and its treatments. Its incidence is approximately 80% in intensive care unit patients, and it manifests as critical illness polyneuropathy, critical illness myopathy, and muscle atrophy. Intensive care unit patients can lose an elevated percentage of their muscle mass in the first days after admission, producing short- and long-term sequelae that affect patients’ quality of life, physical health, and mental health. In 2019, the world was faced with coronavirus disease 2019 (COVID-19), caused by the acute respiratory syndrome coronavirus 2. COVID-19 produces severe respiratory disorders, such as acute respiratory distress syndrome, which increases the risk of developing ICU-AW. COVID-19 patients treated in intensive care units have shown early diffuse and symmetrical muscle weakness, polyneuropathy, and myalgia, coinciding with the clinical presentation of ICU-AW. Besides, these patients require prolonged intensive care unit stays, invasive mechanical ventilation, and intensive care unit pharmacological therapy, which are risk factors for ICU-AW. Thus, the purposes of this review are to discuss the features of ICU-AW and its effects on skeletal muscle. Further, we will describe the mechanisms involved in the probable development of ICU-AW in severe COVID-19 patients.es
dc.description.urihttps://www.pagepressjournals.org/index.php/bam/article/view/10511
dc.identifier.citationEuropean Journal of Translational Myology. Volume 32, Issue 3. 29 September 2022. Article number 10511es
dc.identifier.doiDOI: 10.4081/ejtm.2022.10511
dc.identifier.issn2037-7452
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/49380
dc.language.isoenes
dc.publisherPage Press Publicationses
dc.rightsAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectICU-acquired weakness (ICU-AW)es
dc.subjectCoronavirus Disease 2019es
dc.subjectSkeletal Muscle Atrophyes
dc.subjectCritical Illnesses
dc.titleIntensive care unit-acquired weakness: a review from molecular mechanisms to its impact in COVID-2019es
dc.typeArtículoes
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