CD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cells

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dc.contributor.authorFlores-Santibáñez, Felipe
dc.contributor.authorFernández, Dominique
dc.contributor.authorMeza, Daniel
dc.contributor.authorTejón, Gabriela
dc.contributor.authorVargas, Leonardo
dc.contributor.authorVarela-Nallar, Lorena
dc.contributor.authorArredondo, Sebastián
dc.contributor.authorGuixé, Victoria
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorBono, María Rosa
dc.contributor.authorSauma, Daniela
dc.date.accessioned2023-06-16T21:50:21Z
dc.date.available2023-06-16T21:50:21Z
dc.date.issued2015-12
dc.descriptionIndexación: Scopuses
dc.description.abstractThe CD73 ectonucleotidase catalyses the hydrolysis of AMP to adenosine, an immunosuppressive molecule. Recent evidence has demonstrated that this ectonucleotidase is up-regulated in T helper type 17 cells when generated in the presence of transforming growth factor-β (TGF-β), and hence CD73 expression is related to the acquisition of immunosuppressive potential by these cells. TGF-β is also able to induce CD73 expression in CD8+ T cells but the function of this ectonucleotidase in CD8+ T cells is still unknown. Here, we show that Tc17 cells present high levels of the CD73 ectonucleotidase and produce adenosine; however, they do not suppress the proliferation of CD4+ T cells. Interestingly, we report that adenosine signalling through A2A receptor favours interleukin-17 production and the expression of stem cell-associated transcription factors such as tcf-7 and lef-1 but restrains the acquisition of Tc1-related effector molecules such as interferon-γ and Granzyme B by Tc17 cells. Within the tumour microenvironment, CD73 is highly expressed in CD62L+ CD127+ CD8+ T cells (memory T cells) and is down-regulated in GZMB+ KLRG1+ CD8+ T cells (terminally differentiated T cells), demonstrating that CD73 is expressed in memory/naive cells and is down-regulated during differentiation. These data reveal a novel function of CD73 ectonucleotidase in arresting CD8+ T-cell differentiation and support the idea that CD73-driven adenosine production by Tc17 cells may promote stem cell-like properties in Tc17 cells.es
dc.description.urihttps://onlinelibrary.wiley.com/doi/10.1111/imm.12529
dc.identifier.citationImmunology. Open Access. Volume 146, Issue 4, Pages 582 - 594. 1 December 2015es
dc.identifier.doiDOI: 10.1111/imm.12529
dc.identifier.issn0019-2805
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/50797
dc.language.isoenes
dc.publisherBlackwell Publishing Ltdes
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAdenosinees
dc.subjectCD73es
dc.subjectCell Differentiationes
dc.subjectStem Celles
dc.subjectTc17es
dc.subjectTumour Immunologyes
dc.titleCD73-mediated adenosine production promotes stem cell-like properties in mouse Tc17 cellses
dc.typeArtículoes
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