The Arabidopsis Golgi-localized GDP-L-fucose transporter is required for plant development

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dc.contributor.authorRautengarten, Carsten
dc.contributor.authorEbert, Berit
dc.contributor.authorLiu, Lifeng
dc.contributor.authorStonebloom, Solomon
dc.contributor.authorSmith-Moritz, Andreia M.
dc.contributor.authorPauly, Markus
dc.contributor.authorOrellana, Ariel
dc.contributor.authorScheller, Henrik Vibe
dc.contributor.authorHeazlewood, Joshua L.
dc.date.accessioned2017-01-30T19:06:37Z
dc.date.available2017-01-30T19:06:37Z
dc.date.issued2016-07
dc.descriptionIndexación: Web of Science.es
dc.description.abstractNucleotide sugar transport across Golgi membranes is essential for the luminal biosynthesis of glycan structures. Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP-L-fucose into the Golgi lumen. Using proteo-liposome-based transport assays, we show that GFT preferentially transports GDP-L-fucose over other nucleotide sugars in vitro, while GFT1-silenced plants are almost devoid of L-fucose in cell wall-derived xyloglucan and rhamnogalacturonan II. Furthermore, these lines display reduced L-fucose content in N-glycan structures accompanied by severe developmental growth defects. We conclude that GFT1 is the major nucleotide sugar transporter for import of GDP-L-fucose into the Golgi and is required for proper plant growth and development.es
dc.description.urihttp://www.nature.com/articles/ncomms12119
dc.identifier.citationNature Communications 7, Article number:12119 (2016)es
dc.identifier.issn2041-1723
dc.identifier.otherdoi:10.1038/ncomms12119
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2795
dc.language.isoenes
dc.publisherNATURE PUBLISHING GROUPes
dc.subjectDE-NOVO SYNTHESISes
dc.subjectGALACTOSE TRANSPORTERes
dc.subjectRHAMNOGALACTURONAN-IIes
dc.subjectSUGAR TRANSPORTERSes
dc.subjectN-GLYCANSes
dc.subjectUDP-GALACTOSEes
dc.subjectMUR1 GENEes
dc.subjectTHALIANAes
dc.subjectXYLOGLUCANes
dc.subjectEXPRESSIONes
dc.titleThe Arabidopsis Golgi-localized GDP-L-fucose transporter is required for plant developmentes
dc.typeArtículoes
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