Global prevalence and molecular characterization of extended-spectrum β-lactamase producing-Escherichia coli in dogs and cats – A scoping review and meta-analysis

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dc.contributor.authorSalgado-Caxito, M.
dc.contributor.authorBenavides, J.
dc.contributor.authorAdell, A.
dc.contributor.authorPaes, A.
dc.contributor.authorMoreno-Switt, A.
dc.date.accessioned2024-09-10T17:28:59Z
dc.date.available2024-09-10T17:28:59Z
dc.date.issued2021
dc.descriptionTEXTO COMPLETO EN INGLÉS
dc.description.abstractAntimicrobial resistance (AMR) represents a major threat to human and animal health. Part of the AMR dimension is the circulation of extended-spectrum β-lactamases producing-Escherichia coli (ESBL-E. coli), which is now commonly reported among companion animals. However, the global perspective of the prevalence and population structure of ESBL-E. coli circulating in dogs and cats has not been estimated limiting our understanding of their role in the dissemination of ESBL-E. coli. The aim of this study was to compare the prevalence of ESBL-E. coli between dogs and cats and across countries through meta-analysis. We also performed a scoping review to summarize the current knowledge on ESBL genes and E. coli clones circulating among companion animals. A total of 128 studies published in PubMed, Web of Science, and Scopus up to April 2020 were selected and contained information on prevalence and/or molecular characterization of ESBL genes and ESBL-E. coli clones. Our review shows an increase in the number of publications between 2000 and 2019, concentrated mainly in Europe. Prevalence varied across continents, ranging from 0.63% (Oceania) to 16.56% (Africa) in dogs and from 0% (Oceania) to 16.82% (Asia) in cats. Although there were twice as many studies reporting prevalence on dogs (n = 61) than on cats (n = 32), and only 9 studies focused exclusively on cats, our meta-analysis showed no difference in the global prevalence of ESBL-E. coli between dogs (6.87% [95% CI: 4.46–10.45%]) and cats (5.04% [95% CI: 2.42–10.22%]). A considerable diversity of ESBL genes (n = 60) and sequence types (ST) (n = 171) were recovered from companion animals. ESBL-E. coli encoded by CTX-M-15 (67.5%, 77/114) and SHV-12 (21.9%, 25/114), along with resistant strains of ST38 (22.7%, 15/66) and ST131 (50%, 33/66) were widespread and detected in all continents. While presence of ESBL-E. coli is widespread, the drivers influencing the observed ESBL-E. coli prevalence and the clinical relevance in veterinary medicine and public health along with economic impact of ESBL-E. coli infections among companion animals need to be further investigated.
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S2352771421000264
dc.identifier.citationOne Health Volume, 12 , June 2021, 100236
dc.identifier.doihttps://doi.org/10.1016/j.onehlt.2021.100236
dc.identifier.issn2352-7714
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60030
dc.language.isoen
dc.publisherElsevier
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International
dc.subjectAntimicrobial resistance
dc.subjectCompanion animals
dc.subjectESBL
dc.subjectPets
dc.subjectResistance genes
dc.subjectWorldwide
dc.titleGlobal prevalence and molecular characterization of extended-spectrum β-lactamase producing-Escherichia coli in dogs and cats – A scoping review and meta-analysis
dc.typeArtículo
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