Consequences of nongenomic actions of estradiol on pathogenic genital tract response

Vista sencilla de ítem
dc.contributor.authorSolar, P.
dc.contributor.authorVelasquez, L.
dc.date.accessioned2023-05-16T17:52:52Z
dc.date.available2023-05-16T17:52:52Z
dc.date.issued2013-01
dc.descriptionIndexación: Scopus.es
dc.description.abstractEstradiol is a steroid hormone that regulates the structure and function of the female reproductive system. In addition to its genomic effects, which are mediated by activated nuclear receptors, estradiol elicits a variety of rapid signaling events independently of transcriptional or genomic regulation. These nongenomic actions influence the milieu of the genital tract, which changes the ability of pathogens to infect the genital tract. This review discusses our current knowledge regarding the mechanisms and relevance of nongenomic estradiol signaling in the genital tract that could change the ability of pathogens to invade epithelial cells. PubMed was searched through January 1980 for papers related to estradiol actions in the ovary, fallopian tube, uterus and cervix. The mechanisms conveying these rapid effects consist of a multitude of signaling molecules and include cross-talk with slower transcriptional actions. The nongenomic actions of estradiol that influence the infectious abilities of pathogens occur either directly on the genital tract cells or indirectly by modulating the local and systemic immune systems. Additional in-depth characterization of the response is required before the normal and pathological reproductive functions of the nongenomic estradiol pathway can be targeted for pharmacological intervention. © 2013 Solar and Velasquez; licensee BioMed Central Ltd.es
dc.description.urihttps://jmolecularsignaling.com/articles/10.1186/1750-2187-8-1
dc.identifier.citationJournal of Molecular Signaling, Volume 826, January 2013, Article number 1es
dc.identifier.doi10.1186/1750-2187-8-1
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/49694
dc.language.isoenes
dc.publisherUbiquity Presses
dc.rights.licenseAttribution 3.0 Unported (CC BY 3.0)
dc.rights.urihttps://jmolecularsignaling.com/about#open-access-policy
dc.subjectEstradioles
dc.subjectGenital tractes
dc.subjectImmune responsees
dc.subjectNongenomices
dc.subjectPathogenesises
dc.titleConsequences of nongenomic actions of estradiol on pathogenic genital tract responsees
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Solar_Consequences of nongenomic actions of estradiol on pathogenic genital tract response.pdf
Tamaño:
669.43 KB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista