Effect of Housing Types on Growth, Feeding, Physical Activity, and Anxiety-Like Behavior in Male Sprague-Dawley Rats

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dc.contributor.authorTeske, Jennifer A.
dc.contributor.authorPerez-Leighton, Claudio Esteban
dc.contributor.authorNoble, Emily E.
dc.contributor.authorWang, Chuanfeng
dc.contributor.authorBillington, Charles J.
dc.contributor.authorKotz, Catherine M.
dc.date.accessioned2023-07-14T22:12:53Z
dc.date.available2023-07-14T22:12:53Z
dc.date.issued2016-02
dc.descriptionIndexación: Scopuses
dc.description.abstractBackground: Animal welfare and accurate data collection are equally important in rodent research. Housing influences study outcomes and can challenge studies that monitor feeding, so housing choice needs to be evidence-based. The goal of these studies was to (1) compare established measures of well-being between rodents housed in wire grid-bottom floors with a resting platform compared to solid-bottom floors with bedding and (2) determine whether presence of a chewable device (Nylabone) affects orexin-A-induced hyperphagia. Methods: Rodents were crossed over to the alternate housing twice after 2-week periods. Time required to complete food intake measurements was recorded as an indicator of feasibility. Food intake stimulated by orexin-A was compared with and without the Nylabone. Blood corticosterone and hypothalamic BDNF were assessed. Results: Housing had no effect on growth, energy expenditure, corticosterone, hypothalamic BDNF, behavior, and anxiety measures. Food intake was disrupted after housing cross-over. Time required to complete food intake measurements was significantly higher for solid-bottom bedded cages. The Nylabone had no effect on orexin-A-stimulated feeding. Conclusion: Well-being is not significantly different between rodents housed on grid-bottom floors and those in solid-bottom-bedded cages based on overall growth and feeding but alternating between housing confounds measures of feeding. © Copyright © 2016 Teske, Perez-Leighton, Noble, Wang, Billington and Kotz.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnut.2016.00004/full
dc.identifier.citationFrontiers in Nutrition Volume 34 February 2016 Article number 4es
dc.identifier.doi10.3389/fnut.2016.00004
dc.identifier.issn2296-861X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51672
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAnxietyes
dc.subjectCognitiones
dc.subjectEnvironmental enrichmentes
dc.subjectMicroenvironmentes
dc.subjectStresses
dc.titleEffect of Housing Types on Growth, Feeding, Physical Activity, and Anxiety-Like Behavior in Male Sprague-Dawley Ratses
dc.typeArtículoes
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