Participation of S. Typhimurium cysJIH operon in the H2S-mediated ciprofloxacin resistance in presence of sulfate as sulfur source

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dc.contributor.authorÁlvarez, Ricardo
dc.contributor.authorFrávega, Jorge
dc.contributor.authorRodas, Paula
dc.contributor.authorFuentes, Juan A.
dc.contributor.authorParedes-Sabja, Daniel
dc.contributor.authorCalderón, Iván L.
dc.contributor.authorGil, Fernando
dc.date.accessioned2023-04-05T15:54:16Z
dc.date.available2023-04-05T15:54:16Z
dc.date.issued2015-07
dc.descriptionIndexación: Scopuses
dc.description.abstractH2S production has been proposed as a mechanism to explain bacterial resistance to antibiotics. In this work, we present evidence for the role of the cysJIH operon in resistance to ciprofloxacin mediated by H2S production with different sulfate as the only sulfur source. We found that the products of the cysJIH operon are involved in ciprofloxacin resistance by increasing both, the levels of H2S and reduced thiols apparently counteracting antimicrobial-induced reactive oxygen species (ROS). This protective effect was observed only when bacteria were cultured in the presence of sulfate, but not with cysteine, as the sole sulfur source. © 2015, by the authors.es
dc.description.urihttps://www.mdpi.com/2079-6382/4/3/321
dc.identifier.citationAntibiotics Volume 4, Issue 3, Pages 321 - 32831 July 2015es
dc.identifier.doi10.3390/antibiotics4030321
dc.identifier.issn2079-6382
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48240
dc.language.isoenes
dc.publisherMDPI AGes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectEscherichia Colies
dc.subjectMicrobial Sensitivity Testses
dc.subjectOperones
dc.titleParticipation of S. Typhimurium cysJIH operon in the H2S-mediated ciprofloxacin resistance in presence of sulfate as sulfur sourcees
dc.typeArtículoes
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