Role of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)

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dc.contributor.authorGonzalez, A.
dc.contributor.authorHuerta-Salgado, C.
dc.contributor.authorOrozco-Aguilar, J.
dc.contributor.authorAguirre, F.
dc.contributor.authorTacchi, F.
dc.contributor.authorSimon, F.
dc.contributor.authorCabello-Verrugio, C.
dc.date.accessioned2021-07-27T14:30:17Z
dc.date.available2021-07-27T14:30:17Z
dc.date.issued2020
dc.descriptionIndexación: Scopus.es
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until nonalcoholic steatohepatitis (NASH), a more aggressive form of the disease characterized by steatosis, inflammatory status, and varying liver degrees fibrosis. NAFLD is the most prevalent chronic liver disease worldwide. The causes of NAFLD are diverse and include genetic and environmental factors. The presence of NASH is strongly associated with cirrhosis development and hepatocellular carcinoma, two conditions that require liver transplantation. The liver alterations during NAFLD are well described. Interestingly, this pathological condition also affects other critical tissues and organs, such as skeletal muscle and even the cardiovascular, renal, and nervous systems. Oxidative stress (OS) is a harmful state present in several chronic diseases, such as NAFLD. The purpose of this review is to describe hepatic and extrahepatic dysfunctions in NAFLD. We will also review the influence of OS on the physiopathological events that affect the critical function of the liver and peripheral tissues.es
dc.description.urihttps://www.hindawi.com/journals/omcl/2020/1617805/#copyright
dc.identifier.citationOxidative Medicine and Cellular Longevity, Volume 2020, 2020, Article number 1617805es
dc.identifier.doiDOI: 10.1155/2020/1617805
dc.identifier.issn1942-0900
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/19522
dc.language.isoenes
dc.publisherHindawies
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.subjectCancerses
dc.subjectDevelopmentes
dc.subjectDiseaseses
dc.subjectHistologyes
dc.subjectReviewes
dc.subjectShapees
dc.subjectStresseses
dc.subjectTransplantationes
dc.subjectantioxidantes
dc.subjectreactive nitrogen specieses
dc.titleRole of Oxidative Stress in Hepatic and Extrahepatic Dysfunctions during Nonalcoholic Fatty Liver Disease (NAFLD)es
dc.typeArtículoes
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