Domestic Cat Hepadnavirus and Pathogenic Retroviruses; A Sero-Molecular Survey of Cats in Santiago, Chile

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dc.contributor.authorChoi, Yan Ru
dc.contributor.authorIturriaga, María Paz
dc.contributor.authorNekouei, Omid
dc.contributor.authorTu, Thomas
dc.contributor.authorVan Brussel, Kate
dc.contributor.authorBarrs, Vanessa R.
dc.contributor.authorBeatty, Julia A.
dc.date.accessioned2024-10-15T13:46:54Z
dc.date.available2024-10-15T13:46:54Z
dc.date.issued2024-01
dc.descriptionIndexación: Scopus
dc.description.abstractCat ownership is common in Chile, but data on the regional prevalence of infectious agents are limited. A sero-molecular survey of 120 client- or shelter-owned domestic cats in greater Santiago was performed. Whole blood DNA was tested for the novel hepatitis-B-like virus, domestic cat hepadnavirus (DCH) by conventional PCR (cPCR) and quantitative PCR (qPCR), and for feline leukaemia virus (FeLV) by qPCR. Point-of-care serology for FeLV p27 antigen and antibodies recognising feline immunodeficiency virus (FIV) p15 and p24 was performed. DCH DNA was detected in the serum of 2/120 cats (1.67%). Sequencing and phylogenetic analysis showed that the DCH detected in Chile occupies a position outside the main clustering of DCH in the near-complete genome tree. Progressive (antigen-positive, provirus-positive) and regressive (antigen-negative, provirus-positive) FeLV infections were identified in 6/120 (5%) and 9/120 (7.5%) of cats. A total of 2/120 (1.7%) cats had dual FeLV/FIV infection, and another 2 cats had FIV infection alone. This study shows that the global footprint of DCH includes South America with a low molecular frequency in Chile, similar to that reported in the USA. Progressive FeLV infection is relatively common in urban Chile, and male cats are at greater risk than females. Testing and control measures for pathogenic retroviruses are indicated. The potential impact of FeLV, FIV and DCH on Chile’s wildcat species is worthy of further investigation
dc.identifier.citationViruses Volume 16, Issue 1 January 2024 Article number 46
dc.identifier.doi10.3390/v16010046
dc.identifier.issn1999-4915
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/61305
dc.language.isoen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.rights.licenseAttribution 4.0 International CC BY 4.0
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectcat
dc.subjecthepadnavirus
dc.subjectfeline leukaemia virus
dc.subjectfeline immunodeficiency virus
dc.subjectSouth America
dc.subjectprogressive
dc.titleDomestic Cat Hepadnavirus and Pathogenic Retroviruses; A Sero-Molecular Survey of Cats in Santiago, Chile
dc.typeArtículo
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