Sporulation and Germination in Clostridial Pathogens

Vista sencilla de ítem
dc.contributor.authorShen, Aimee
dc.contributor.authorEdwards, Adrianne N.
dc.contributor.authorSarker, Mahfuzur R.
dc.contributor.authorParedes-Sabja, Daniel
dc.date.accessioned2024-06-18T16:57:50Z
dc.date.available2024-06-18T16:57:50Z
dc.date.issued2019-12
dc.descriptionIndexación: Scopus.
dc.description.abstractAs obligate anaerobes, clostridial pathogens depend on their metabolically dormant, oxygen-tolerant spore form to transmit disease. However, the molecular mechanisms by which those spores germinate to initiate infection and then form new spores to transmit infection remain poorly understood. While sporulation and germination have been well characterized in Bacillus subtilis and Bacillus anthracis, striking differences in the regulation of these processes have been observed between the bacilli and the clostridia, with even some conserved proteins exhibiting differences in their requirements and functions. Here, we review our current understanding of how clostridial pathogens, specifically Clostridium perfringens, Clostridium botulinum, and Clostridioides difficile, induce sporulation in response to environmental cues, assemble resistant spores, and germinate metabolically dormant spores in response to environmental cues. We also discuss the direct relationship between toxin production and spore formation in these pathogens.
dc.description.urihttps://journals.asm.org/doi/epub/10.1128/microbiolspec.gpp3-0017-2018
dc.identifier.citationMicrobiology Spectrum Volume 7, Issue 6 December 2019 Article number GPP3-0017-2018
dc.identifier.doi10.1128/microbiolspec.GPP3-0017-2018
dc.identifier.issn2165-0497
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/57711
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.subjectAnimals
dc.subjectClostridium
dc.subjectClostridium Infections
dc.subjectHumans
dc.subjectSpores, Bacterial
dc.titleSporulation and Germination in Clostridial Pathogens
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
shen-et-al-2019-sporulation-and-germination-in-clostridial-pathogens.pdf
Tamaño:
3.11 MB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista