The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone function

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dc.contributor.authorFaunes, Fernando
dc.contributor.authorGundermann, Daniel G.
dc.contributor.authorMuñoz, Rosana
dc.contributor.authorBruno, Renzo
dc.contributor.authorLarraín, Juan
dc.date.accessioned2024-05-28T16:37:40Z
dc.date.available2024-05-28T16:37:40Z
dc.date.issued2017-06
dc.descriptionIndexación: Scopus
dc.description.abstractMetamorphosis is a classic example of developmental transition, which involves important morphological and physiological changes that prepare the organism for the adult life. It has been very well established that amphibian metamorphosis is mainly controlled by Thyroid Hormone (TH). Here, we show that the heterochronic gene Lin28 is downregulated during Xenopus laevis metamorphosis. Lin28 overexpression before activation of TH signaling delays metamorphosis and inhibits the expression of TH target genes. The delay in metamorphosis is rescued by incubation with exogenous TH, indicating that Lin28 works upstream or parallel to TH. High-throughput analyses performed before any delay on metamorphosis or change in TH signaling showed that overexpression of Lin28 reduces transcript levels of several hormones secreted by the pituitary, including the Thyroid-Stimulating Hormone (TSH), and regulates the expression of proteins involved in TH transport, metabolism and signaling, showing that Lin28 disrupts TH function at different levels. Our data demonstrates that the role of Lin28 in controlling developmental transitions is evolutionary conserved and establishes a functional interaction between Lin28 and thyroid hormone function introducing a new regulatory step in perinatal development with implications for our understanding of endocrine disorders. © 2017 The Authors
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0012160616306716?via%3Dihub
dc.identifier.citationDevelopmental Biology Volume 425, Issue 2, Pages 142 - 15115 May 2017
dc.identifier.doi10.1016/j.ydbio.2017.03.026
dc.identifier.issn0012-1606
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/57181
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.rights.licenseCC BY 4.0 DEED Atribución 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectHeterochronic genes
dc.subjectLin28
dc.subjectMetamorphosis
dc.subjectPituitary
dc.subjectThyroid hormone
dc.subjectXenopus laevis
dc.titleThe heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone function
dc.typeArtículo
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