Quercetin Affects Erythropoiesis and Heart Mitochondrial Function in Mice

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dc.contributor.authorRuiz, Lina M.
dc.contributor.authorSalazar, Celia
dc.contributor.authorJensen, Erik
dc.contributor.authorRuiz, Paula A.
dc.contributor.authorTiznado, William
dc.contributor.authorQuintanilla, Rodrigo A.
dc.contributor.authorBarreto, Marlen
dc.contributor.authorElorza, Alvaro A.
dc.date.accessioned2023-08-29T19:34:50Z
dc.date.available2023-08-29T19:34:50Z
dc.date.issued2015
dc.descriptionIndexación: Scopuses
dc.description.abstractQuercetin, a dietary flavonoid used as a food supplement, showed powerful antioxidant effects in different cellular models. However, recent in vitro and in vivo studies in mammals have suggested a prooxidant effect of quercetin and described an interaction with mitochondria causing an increase in O2- production, a decrease in ATP levels, and impairment of respiratory chain in liver tissue. Therefore, because of its dual actions, we studied the effect of quercetin in vivo to analyze heart mitochondrial function and erythropoiesis. Mice were injected with 50 mg/kg of quercetin for 15 days. Treatment with quercetin decreased body weight, serum insulin, and ceruloplasmin levels as compared with untreated mice. Along with an impaired antioxidant capacity in plasma, quercetin-treated mice showed a significant delay on erythropoiesis progression. Heart mitochondrial function was also impaired displaying more protein oxidation and less activity for IV, respectively, than no-treated mice. In addition, a significant reduction in the protein expression levels of Mitofusin 2 and Voltage-Dependent Anion Carrier was observed. All these results suggest that quercetin affects erythropoiesis and mitochondrial function and then its potential use as a dietary supplement should be reexamined. © 2015 Lina M. Ruiz et al.es
dc.description.urihttps://www.hindawi.com/journals/omcl/2015/836301/
dc.identifier.citationOxidative Medicine and Cellular Longevity Volume 20152015 Article number 836301es
dc.identifier.doi10.1155/2015/836301
dc.identifier.issn1942-0900
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52899
dc.language.isoenes
dc.publisherHindawi Publishing Corporationes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.titleQuercetin Affects Erythropoiesis and Heart Mitochondrial Function in Micees
dc.typeArtículoes
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