Clostridium difficile associated infections: An updated view

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dc.contributor.authorHernández-Rocha, C.
dc.contributor.authorNaour, S.
dc.contributor.authorÁlvarez-Lobos, M.
dc.contributor.authorParedes-Sabja, D.
dc.date.accessioned2023-06-23T18:25:29Z
dc.date.available2023-06-23T18:25:29Z
dc.date.issued2012-08
dc.descriptionIndexación: Scopus.es
dc.description.abstractClostridium difficile is an emerging anaerobic, spore forming pathogen, recognized as the etiological agent of ~ 30% of antibiotic associated diarrheas. Clinical symptoms can fluctuate from mild to moderate diarrhea, pseudomembranous colitis and toxic megacolon. The incidence of C. diffi cile associated infections (CDAI) is ~ 1% of total hospitalized patients. CDAI has a mortality rate of ~1 to 5%, and a relapse rate of ~ 20%. The appearance of severe outbreaks of CDAI could be attributed to changes in the production of the two major virulence factors, the enterotoxins TcdA and TcdB, which produce massive epithelial damage. C. diffi cile spores play an essential role in transmission, initiation and persistence of CDAI. Recent advances in detection methods, development of novel therapies and prevention methods could allow a reduction on the frequency of CDAI. The objective of this review is to provide an updated view on the mechanisms of pathogenesis, epidemiology, risk factors, detection methods, treatment and prevention of CDAI.es
dc.description.urihttps://www-scielo-cl.recursosbiblioteca.unab.cl/scielo.php?script=sci_arttext&pid=S0716-10182012000400011&lng=en&nrm=iso&tlng=en
dc.identifier.citationRevista Chilena de Infectologia, Volume 29, Issue 4, Pages 434 - 445, August 2012es
dc.identifier.doi10.4067/S0716-10182012000400011
dc.identifier.issn0716-1018
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/51040
dc.language.isoeses
dc.publisherSociedad Chilena de Infectologíaes
dc.rights.licenseAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.subjectAntibiotic associated colitises
dc.subjectC. difficilees
dc.subjectCdaies
dc.subjectPseudomembranous colitises
dc.subjectSporeses
dc.subjectToxic megacolones
dc.titleClostridium difficile associated infections: An updated viewes
dc.title.alternativeInfecciones causadas por clostridium difficile: Una visión actualizadaes
dc.typeArtículoes
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