Thymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Mice

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dc.contributor.authorHidalgo, Yessia
dc.contributor.authorNúñez, Sarah
dc.contributor.authorFuenzalida, Maria Jose
dc.contributor.authorFlores Santibáñez, Felipe
dc.contributor.authorSáez, Pablo J.
dc.contributor.authorDorner, Jessica
dc.contributor.authorLennon Dumenil, Ana-Maria
dc.contributor.authorMartínez, Victor
dc.contributor.authorZorn, Emmanuel
dc.contributor.authorRosemblatt, Mario
dc.contributor.authorSauma, Daniela
dc.contributor.authorBono, Maria Rosa
dc.date.accessioned2022-07-14T19:00:10Z
dc.date.available2022-07-14T19:00:10Z
dc.date.issued2020-04
dc.descriptionIndexación: Scopuses
dc.description.abstractSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by the activation of autoreactive T and B cells, autoantibody production, and immune complex deposition in various organs. Previous evidence showed abnormal accumulation of B cells in the thymus of lupus-prone mice, but the role of this population in the progression of the disease remains mostly undefined. Here we analyzed the spatial distribution, function, and properties of this thymic B cell population in the BWF1 murine model of SLE. We found that in diseased animals, thymic B cells proliferate, and cluster in structures that resemble ectopic germinal centers. Moreover, we detected antibody-secreting cells in the thymus of diseased-BWF1 mice that produce anti-dsDNA IgG autoantibodies. We also found that thymic B cells from diseased-BWF1 mice induced the differentiation of thymocytes to follicular helper T cells (TFH). These data suggest that the accumulation of B cells in the thymus of BWF1 mice results in the formation of germinal center-like structures and the expansion of a TFH population, which may, in turn, activate and differentiate B cells into autoreactive plasma cells. Therefore, the thymus emerges as an important niche that supports the maintenance of the pathogenic humoral response in the development of murine SLE. © Copyright © 2020 Hidalgo, Núñez, Fuenzalida, Flores-Santibáñez, Sáez, Dorner, Lennon-Dumenil, Martínez, Zorn, Rosemblatt, Sauma and Bono.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2020.00696/full
dc.identifier.citationFrontiers in Immunology Volume 1128 April 2020 Article number 696es
dc.identifier.doi10.3389/fimmu.2020.00696
dc.identifier.issn1664-3224
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23237
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectFollicular helper T cellses
dc.subjectGerminal centeres
dc.subjectPlasma cellses
dc.subjectSystemic lupus erythematosuses
dc.subjectThymic B cellses
dc.titleThymic B Cells Promote Germinal Center-Like Structures and the Expansion of Follicular Helper T Cells in Lupus-Prone Micees
dc.typeArtículoes
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