Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases

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dc.contributor.authorFunes, S.C.
dc.contributor.authorRios, M.
dc.contributor.authorFernández-Fierro, A.
dc.contributor.authorCovián, C.
dc.contributor.authorBueno, S.M.
dc.contributor.authorRiedel, C.A.
dc.contributor.authorMackern-Oberti, J.P.
dc.contributor.authorKalergis, A.M.
dc.date.accessioned2021-10-18T23:03:13Z
dc.date.available2021-10-18T23:03:13Z
dc.date.issued2020-07
dc.descriptionIndexación: Scopus.es
dc.description.abstractHeme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity. © Copyright © 2020 Funes, Rios, Fernández-Fierro, Covián, Bueno, Riedel, Mackern-Oberti and Kalergis.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fimmu.2020.01467/full
dc.identifier.citationFrontiers in Immunology Open Access Volume 1123 July 2020 Article number 1467es
dc.identifier.doi10.3389/fimmu.2020.01467
dc.identifier.issn1664-3224
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/20510
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectautoimmunityes
dc.subjectheme oxygenase 1es
dc.subjectHO-1es
dc.subjectInflammationes
dc.subjectnaturally derived compoundses
dc.titleNaturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseaseses
dc.typeArtículoes
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