Identification of Novel Components of the Unfolded Protein Response in Arabidopsis

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dc.contributor.authorHossain, MA
dc.contributor.authorHenriquez-Valencia, C
dc.contributor.authorGomez-Paez, M
dc.contributor.authorMedina, J
dc.contributor.authorOrellana, A
dc.contributor.authorVicente-Carbajosa, J
dc.contributor.authorZouhar, J
dc.date.accessioned2016-06-21T15:15:34Z
dc.date.available2016-06-21T15:15:34Z
dc.date.issued2016
dc.descriptionIndexación: Web of Sciencees
dc.description.abstractUnfavorable environmental and developmental conditions may cause disturbances in protein folding in the endoplasmic reticulum (ER) that are recognized and counteracted by components of the Unfolded Protein Response (UPR) signaling pathways. The early cellular responses include transcriptional changes to increase the folding and processing capacity of the ER. In this study, we systematically screened a collection of inducible transgenic Arabidopsis plants expressing a library of transcription factors for resistance toward UPR-inducing chemicals. We identified 23 candidate genes that may function as novel regulators of the UPR and of which only three genes (bZIP10, TBF1, and NF-YB3) were previously associated with the UPR. The putative role of identified candidate genes in the UPR signaling is supported by favorable expression patterns in both developmental and stress transcriptional analyses. We demonstrated that WRKY75 is a genuine regulator of the ER-stress cellular responses as its expression was found to be directly responding to ER stress-inducing chemicals. In addition, transgenic Arabidopsis plants expressing WRKY75 showed resistance toward salt stress, connecting abiotic and ER-stress responses.es
dc.description.urihttp://journal.frontiersin.org/article/10.3389/fpls.2016.00650/full
dc.identifier.citationFront. Plant Sci., 12 May 2016es
dc.identifier.issn1664-462X
dc.identifier.otherhttp://dx.doi.org/10.3389/fpls.2016.00650
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/823
dc.language.isoenes
dc.publisherFRONTIERS MEDIAes
dc.subjectENDOPLASMIC-RETICULUM STRESSes
dc.subjectTETHERED TRANSCRIPTION FACTORes
dc.subjectGENE-EXPRESSIONes
dc.subjectSALT STRESSes
dc.subjectER STRESSes
dc.subjectMESSENGER-RNAes
dc.subjectTRANSMEMBRANE PROTEINes
dc.subjectUBIQUITIN LIGASEes
dc.subjectIRE1es
dc.subjectTHALIANAes
dc.titleIdentification of Novel Components of the Unfolded Protein Response in Arabidopsises
dc.typeArtículoes
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