Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish

Vista sencilla de ítem
dc.contributor.authorGarcía-López, Juan P.
dc.contributor.authorGrimaldi, Alexandre
dc.contributor.authorChen, Zelin
dc.contributor.authorMeneses, Claudio
dc.contributor.authorBravo-Tello, Karina
dc.contributor.authorBresciani, Erica
dc.contributor.authorBanderas, Alvaro
dc.contributor.authorBurgess, Shawn M.
dc.contributor.authorHernández, Pedro P.
dc.contributor.authorFeijoo, Carmen G.
dc.date.accessioned2023-10-12T14:46:26Z
dc.date.available2023-10-12T14:46:26Z
dc.date.issued2023-12
dc.descriptionIndexación: Scopuses
dc.description.abstractThe current view of hematopoiesis considers leukocytes on a continuum with distinct developmental origins, and which exert non-overlapping functions. However, there is less known about the function and phenotype of ontogenetically distinct neutrophil populations. In this work, using a photoconvertible transgenic zebrafish line; Tg(mpx:Dendra2), we selectively label rostral blood island-derived and caudal hematopoietic tissue-derived neutrophils in vivo during steady state or upon injury. By comparing the migratory properties and single-cell expression profiles of both neutrophil populations at steady state we show that rostral neutrophils show higher csf3b expression and migration capacity than caudal neutrophils. Upon injury, both populations share a core transcriptional profile as well as subset-specific transcriptional signatures. Accordingly, both rostral and caudal neutrophils are recruited to the wound independently of their distance to the injury. While rostral neutrophils respond uniformly, caudal neutrophils respond heterogeneously. Collectively, our results reveal that co-existing neutrophils populations with ontogenically distinct origin display functional differences.es
dc.identifier.citationNature Communications, Volume 14, Issue 1, December 2023, Article number 5292es
dc.identifier.doi10.1038/s41467-023-40662-7en
dc.identifier.issn2041-1723
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/53443
dc.language.isoenes
dc.publisherNature Researches
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectAnimalses
dc.subjectAnimals, Genetically Modifiedes
dc.subjectHematopoiesises
dc.subjectNeutrophilses
dc.subjectZebrafishes
dc.subjectZebrafish Proteinses
dc.titleOntogenetically distinct neutrophils differ in function and transcriptional profile in zebrafishes
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
s41467-023-40662-7.pdf
Tamaño:
3.03 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLÉS
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista