Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain
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Fecha
2014-07
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
BioMed Central Ltd.
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Background: Opioids have been used for the management of pain and coadministration of two opioids may
induce synergism. In a model of tonic pain, the acetic acid writhing test and in a phasic model, the hot plate, the
antinociceptive interaction between fentanyl, methadone, morphine, and tramadol was evaluated.
Results: The potency of opioids in the writhing test compared to the hot plate assay was from 2.5 (fentanyl) to
15.5 (morphine) times, respectively. The ED50 was used in a fixed ratio for each of the six pairs of opioid
combinations, which, resulted in a synergistic antinociception except for methadone/tramadol and fentanyl/
tramadol which were additive, in the hot plate. The opioid antagonists naltrexone, naltrindole and nor-binaltorphimine,
suggests that the synergism of morphine combinations are due to the activation of MOR subtypes with partially
contribution of DOR and KOR, however fentanyl and methadone combinations are partially due to the activation of
MOR and DOR subtypes and KOR lack of participation. The antinociceptive effects of tramadol combinations, are
partially due to the activation of MOR, DOR and KOR opioid subtypes.
Conclusion: These results suggets that effectiveness and magnitude of the interactions between opioids are
dependent on pain stimulus intensity.
Notas
Indexación: Scopus.
Palabras clave
Interaction Opioid-Opioid, Acetic Acid Writhing Test, Hot Plate Assay, Isobolographic Analysis, Synergism
Citación
Journal of Biomedical Science. Volume 21, Issue 1. 15 July 2014. Article number 62
DOI
DOI: 10.1186/s12929-014-0062-6