Meloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cells

Vista sencilla de ítem
dc.contributor.authorIturriaga, M.P.
dc.contributor.authorParedes, R.
dc.contributor.authorArias, J.I.
dc.contributor.authorTorres, C.G.
dc.date.accessioned2017-12-14T13:32:21Z
dc.date.available2017-12-14T13:32:21Z
dc.date.issued2017-06
dc.descriptionIndexación: Web of Science; Scopus.es_CL
dc.description.abstractCyclooxygenase (COX)-2 expression is positively correlated with malignant features in canine mammary carcinomas. Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit COX activity and may therefore possess anticancer effects. Meloxicam is an NSAID that is widely used in human and veterinary medicine. High concentrations of meloxicam have been reported to be antitumorigenic in vitro; however, the effect of meloxicam at concentrations that are equivalent to those that can be obtained in vivo remains unknown. In the current study, the in vitro effects of low-dose meloxicam (0.25 μg/ml) on CF41.Mg canine mammary carcinoma cells were evaluated. The effects on cell proliferation, apoptosis, cell migration and invasion, in addition to the expression of different molecules associated with tumor invasiveness were analyzed. No effect on cell viability and apoptosis were observed. However, cell migration and invasion were significantly reduced following treatment with meloxicam. MMP-2 expression and activity were similarly reduced, explaining the impaired cell invasion. In addition, β-catenin expression was downregulated, while its phosphorylation increased. These results indicate that 0.25 μg/ml meloxicam reduces cell migration and invasion, in part through modulating MMP-2 and β-catenin expression. Additional studies are required to elucidate the mechanism associated with the anti-invasive effect of meloxicam on CF41.Mg cells. The results of the present study suggest that meloxicam has a potential adjunctive therapeutic application, which could be useful in controlling the invasion and metastasis of canine mammary carcinomas.es_CL
dc.description.urihttps://www.spandidos-publications.com/10.3892/ol.2017.6400
dc.identifier.citationOncology Letters. Volume 14, Issue 2, 2017, Pages 2198-2206es_CL
dc.identifier.issn1792-1074
dc.identifier.otherhttps://doi.org/10.3892/ol.2017.6400
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/4892
dc.language.isoenes_CL
dc.publisherSpandidos Publicationses_CL
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCanine mammary carcinomaes_CL
dc.subjectCell invasiones_CL
dc.subjectCyclooxygenase-2es_CL
dc.subjectMeloxicames_CL
dc.titleMeloxicam decreases the migration and invasion of CF41.Mg canine mammary carcinoma cellses_CL
dc.typeArtículoes_CL
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Iturriaga_M_Meloxicam_decreases.pdf
Tamaño:
1.41 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLES
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista