Sepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patients

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dc.contributor.authorPrado, Yolanda
dc.contributor.authorTapia, Pablo
dc.contributor.authorEltit, Felipe
dc.contributor.authorReyes-Martínez, Cristian
dc.contributor.authorFeijóo, Carmen G.
dc.contributor.authorLlancalahuen, Felipe M.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorCabello-Verrugio, Claudio
dc.contributor.authorStehberg, Jimmy
dc.contributor.authorSimon, Felipe
dc.date.accessioned2023-09-01T13:42:42Z
dc.date.available2023-09-01T13:42:42Z
dc.date.issued2023-02
dc.descriptionIndexación: Scopuses
dc.description.abstractSepsis syndrome is a highly lethal uncontrolled response to an infection, which is characterized by sepsis-induced coagulopathy (SIC). High-density lipoprotein (HDL) exhibits antithrombotic activity, regulating coagulation in vascular endothelial cells. Sepsis induces the release of several proinflammatory molecules, including reactive oxygen species, which lead to an increase in oxidative stress in blood vessels. Thus, circulating lipoproteins, such as HDL, are oxidized to oxHDL, which promotes hemostatic dysfunction, acquiring prothrombotic properties linked to the severity of organ failure in septic-shock patients (SSP). However, a rigorous and comprehensive investigation demonstrating that oxHDL is associated with a coagulopathy-associated deleterious outcome of SSP, has not been reported. Thus, we investigated the participation of plasma oxHDL in coagulopathy-associated sepsis pathogenesis and elucidated the underlying molecular mechanism. A prospective study was conducted on 42 patients admitted to intensive care units, (26 SSP and 16 non-SSP) and 39 healthy volunteers. We found that an increased plasma oxHDL level in SSP was associated with a prothrombotic phenotype, increased mortality and elevated risk of death, which predicts mortality in SSP. The underlying mechanism indicates that oxHDL triggers an endothelial protein expression reprogramming of coagulation factors and procoagulant adhesion proteins, to produce a prothrombotic environment, mainly mediated by the endothelial LOX-1 receptor. Our study demonstrates that an increased plasma oxHDL level is associated with coagulopathy in SSP through a mechanism involving the endothelial LOX-1 receptor and endothelial protein expression regulation. Therefore, the plasma oxHDL level plays a role in the molecular mechanism associated with increased mortality in SSP. © 2023 by the authors.es
dc.description.urihttps://www.mdpi.com/2076-3921/12/3/543
dc.identifier.citationAntioxidants Volume 12, Issue 3February 2023 Article number 543es
dc.identifier.doi10.3390/antiox12030543
dc.identifier.issn2076-3921
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52949
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectCoagulationes
dc.subjectCoagulopathyes
dc.subjectMortalityes
dc.subjectOxidized HDLes
dc.subjectSepsises
dc.titleSepsis-Induced Coagulopathy Phenotype Induced by Oxidized High-Density Lipoprotein Associated with Increased Mortality in Septic-Shock Patientses
dc.typeArtículoes
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