Composition, taxonomy and functional diversity of the oropharynx microbiome in individuals with schizophrenia and controls

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dc.contributor.authorCastro-Nallar, Eduardo
dc.contributor.authorBendall, Matthew L.
dc.contributor.authorPérez-Losada, Marcos
dc.contributor.authorSabuncyan, Sarven
dc.contributor.authorSeverance, Emily G.
dc.contributor.authorDickerson, Faith B.
dc.contributor.authorSchroeder, Jennifer R.
dc.contributor.authorYolken, Robert H.
dc.contributor.authorCrandall, Keith A.
dc.date.accessioned2023-08-28T17:14:31Z
dc.date.available2023-08-28T17:14:31Z
dc.date.issued2015
dc.descriptionIndexación: Scopuses
dc.description.abstractThe role of the human microbiome in schizophrenia remains largely unexplored. The microbiome has been shown to alter brain development and modulate behavior and cognition in animals through gut-brain connections, and research in humans suggests that it may be a modulating factor in many disorders. This study reports findings from a shotgun metagenomic analysis of the oropharyngeal microbiome in 16 individuals with schizophrenia and 16 controls. High-level differences were evident at both the phylum and genus levels, with Proteobacteria, Firmicutes, Bacteroidetes, and Actinobacteria dominating both schizophrenia patients and controls, and Ascomycota being more abundant in schizophrenia patients than controls. Controls were richer in species but less even in their distributions, i.e., dominated by fewer species, as opposed to schizophrenia patients. Lactic acid bacteria were relatively more abundant in schizophrenia, including species of Lactobacilli and Bifidobacterium, which have been shown to modulate chronic inflammation. We also found Eubacterium halii, a lactate-utilizing species. Functionally, the microbiome of schizophrenia patients was characterized by an increased number of metabolic pathways related to metabolite transport systems including siderophores, glutamate, and vitamin B12. In contrast, carbohydrate and lipid pathways and energy metabolism were abundant in controls. These findings suggest that the oropharyngeal microbiome in individuals with schizophrenia is significantly different compared to controls, and that particular microbial species and metabolic pathways differentiate both groups. Confirmation of these findings in larger and more diverse samples, e.g., gut microbiome, will contribute to elucidating potential links between schizophrenia and the human microbiota. © 2015 Castro-Nallar et al.es
dc.description.urihttps://peerj.com/articles/1140/
dc.identifier.citationPeerJ Volume 2015, Issue 82015 Article number e1140es
dc.identifier.doi10.7717/peerj.1140
dc.identifier.issn2167-8359
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52871
dc.language.isoenes
dc.publisherPeerJ Inc.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectBiomarkerses
dc.subjectFunctional diversityes
dc.subjectLactic acid bacteriaes
dc.subjectMetagenomicses
dc.subjectMicrobial abundancees
dc.subjectMicrobial diversityes
dc.subjectMicrobiomees
dc.subjectPathoScopees
dc.subjectSchizophreniaes
dc.subjectShotgun sequencinges
dc.titleComposition, taxonomy and functional diversity of the oropharynx microbiome in individuals with schizophrenia and controlses
dc.typeArtículoes
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