Imprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells

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dc.contributor.authorElgueta, Raul
dc.contributor.authorSepulveda, Fernando E.
dc.contributor.authorVilches, Felipe
dc.contributor.authorVargas, Leonardo
dc.contributor.authorMora, J. Rodrigo
dc.contributor.authorBono, Maria Rosa
dc.contributor.authorRosemblatt, Mario
dc.date.accessioned2024-07-30T16:30:22Z
dc.date.available2024-07-30T16:30:22Z
dc.date.issued2008-05-15
dc.descriptionINDEXACIÓN: WEB OF SCIENCE.
dc.description.abstractIt has recently been shown that IL-4 can educate dendritic cells (DC) to differentially affect T cell effector activity. In this study, we show that IL-4 can also act upon DC to instruct naive T cells to express the gut-associated homing receptor CCR9. Thus, effector T cells generated after coculture with mesenteric lymph node (MLN)-DC show a higher expression of CCR9 when activated in the presence of IL-4. In contrast, IL-4 had no effect on CCR9 expression when naive T cells were polyclonally activated in the absence of MLN-DC, suggesting that the effect of IL-4 on CCR9 expression passed through DC. Indeed, T cells activated by MLN-DC from IL-4R alpha(-/-) mice showed a much lower CCR9 expression and a greatly reduced migration to the small intestine than T cells activated by wild-type MLN-DC even in-the presence of IL-4. Consistent with the finding that the vitamin A metabolite retinoic acid (RA) induces gut-homing molecules on T cells, we further demonstrate that IL-4 up-regulated retinaldehyde dehydrogenase 2 mRNA on MLN-DC, a critical enzyme involved in the synthesis of RA. Moreover, LE135, a RA receptor antagonist, blocked the increased expression of CCR9 driven by IL-4-treated MLN-DC. Thus, besides the direct effect of RA on T cell gut tropism, our results show that the induction of a gut-homing phenotype on CD4(+) T cells is also influenced by the effect of IL-4 on gut-associated DC.
dc.description.urihttps://watermark-silverchair-com.recursosbiblioteca.unab.cl/zim01008006501.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAABfMwggXvBgkqhkiG9w0BBwagggXgMIIF3AIBADCCBdUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM8ABYrS9UJW38ICJIAgEQgIIFpkp9V8V47BP33O-QiDsy9yuKmG8XfRePyEb_C8mEhgjwvYoIW0F43GOVBR6rlmY3kYmAvLI-hc7B3Em35jlFW39E7Tq2c04UB1pL9ZG7GM-JHsLKSfeIvtKl4hunJ-OTKCwG3Cw2aeoRoNbIE2bQH9cdJGTIpouZ27N232_H9-W9d1alJDhqvizuZ0cbESxiROQzx3mLLzdxfuuhyCwc1-LSAQ18ejvYTYOdDosRRU2Hs_0srfzHoUjCDCpi-waqclLFyftCyXsprx_YcG-cAVgAZXu6tnvgqs6YCw2Pc8pW-UYiV8JzhAdhlJ7Cql7F_EdMagvdnb63Oz5VnE6et3kHR_ESXIiqtHBxRa2a3w5PMezL8cOqVLNpg3jYTk6g9Tb8qEf7hgkSEVVLCj72XyKRahzn7XkooAVLPO9SWMp-eLldk4PlsTmELDmm5Q-VVQbEa9cBdhF8yYicosTHzqtOM7g-_9qIJxrAxzvwCsZs_tu1F2XqGeK5HC2Y6cGyX64_ULwRBul2bPjVVEYhl0WDqfGB-5MRO5eV1gmY34CUrbgnIA5DALtz30FrP20kn6ahGkYxyorMTTalCiSH8IhDa-Ipgw_1XgxIE3iF3oEG-iuGxq9lZuTQD576HW5gcsi5KpEaq9JmTfUfmZWWKv7dUzWFXCwCUvANXQpkn2DhTKdFFoS5rv11sAZZF24OgANIixtsnvKUg4TpUr7UwHd3R0rb1p1p_RqWHYBHRHx11p_Gz6uqzi_Q-yCPnefRNczvBAa40tMdqZPf4e1-B47qL2ECrGmn_GBZFsdmls6Zk0kCqEa4EhsJApiRDPbJMB6hEwC8_BAouu8kyW0O5TZug1tp_-WXkwJAnltldB551eP7-cEq8jz6GE7vpjcIvd4nnzF1CTXoOeONd8x4wBDYCFQ9nbo5BFElH1zTUddzYqCEQKosgeGKXw2tdOfwY7ZlmLYhFLdzA4S4BEwMDgVokLYjACMhFf7MDXNqE_D8rDNFcodXyD2iDh50C9ueD7_iH6TnmfwFwZiFmGzK-fmMAHQKFRDkjfIzKOEgFYvCznoIPzZoQWxCENmLg-L90bgevhS5gF0BDtlpFc29Depp5az44111MU79YmBVe3QOiXkJRoQDjXmEEnOVgdHcMg82-6wzha8ahpgO-Zkc8Mk5zvqwaut1I1q0PxFC7FEUrR5JYIhriw6y5EwQtBcHC1XlMZXwu4QucbqqGHhTkVQBD2uzoQuvmJ0cac2N8cS0pQm4jOqhufqlrxUlM5yk3Mcax9fCwl8L_VLFpVF0Wh4w1_U-n37yE9Fek2dGt69AdHkeo_2sYheBrrPSkEnl24hpykf3AjNE0uHnUznmSxzkD7mXAdmT-QFWComUlre6h4S5VaQsMy9ruVmNpVNUyg_tMoXJR0iKTGO6sReOjhTQ2Ks_wuK1kPTCtoTdJgjOh1AnamDsHYQJ9bXbOcAkFHDutalGjFKI5gboUR9tVkZaM1xFJQEGI4JsY4iEMbjnXvOe0BPNHIa55NYA5DkLsnY9uYFFgw8tiTgF0wab__LNqFSGJkkNkfiN6FQeRlgaxvAmbPdknK-nKKXAjmaXNYmotc4P7u5AD-WU1cbyjyte2AyqIE5jsMko7RpRxEnGXVKB7g_LZwrCJn2BOV7EXToaLTTvmdk8GJaipSly2g6v5hQ-JZ87o7IYTVQkjehOo1oWizt5VtbOqkJRpbwB0qOUJ_GJ2n1H1zmZvZTnb9UMvdnxq6WHDP20FHo-PwhBekyVEg6GirJi_-kqT84ZnkoGjeQ4YYZkNu0gTFfRK3BrjLgmwktxFV360FcOoC5wPb6p_p5ze63ntnKbCakIReTMoI3bCP0XSlaqAQKxn9Q-538wGGyKqZ895HDIfxHdY4fA-XCjhC8gfEH3-2AA5ZFlK0mFQQ
dc.identifier.citationJOURNAL OF IMMUNOLOGY, Volume 180, Issue 10, Page 6501-6507
dc.identifier.doi10.4049/jimmunol.180.10.6501
dc.identifier.issn0022-1767
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/58859
dc.language.isoen
dc.publisherAmerican Association of Immunologists
dc.subjectPEYERS PATCH
dc.subjectINFLAMED SKIN
dc.subjectTISSUE
dc.subjectGUT
dc.subjectLYMPHOCYTES
dc.subjectMEMORY
dc.subjectLOCALIZATION
dc.subjectGENERATION
dc.subjectCHEMOKINES
dc.subjectEXPRESSION
dc.titleImprinting of CCR9 on CD4 T cells requires IL-4 signaling on mesenteric lymph node dendritic cells
dc.typeArtículo
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