The insula modulates arousal-induced reluctance to try novel tastes through adrenergic transmission in the rat

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dc.contributor.authorRojas, Sebastián
dc.contributor.authorDiaz-Galarce, Raúl
dc.contributor.authorJerez-Baraona, Juan Manuel
dc.contributor.authorQuintana-Donoso, Daisy
dc.contributor.authorMoraga-Amaro, Rodrigo
dc.contributor.authorStehberg, Jimmy
dc.date.accessioned2023-05-11T17:58:57Z
dc.date.available2023-05-11T17:58:57Z
dc.date.issued2015-06
dc.descriptionIndexación: Scopuses
dc.description.abstractReluctance to try novel tastes (neophobia) can be exacerbated in arousing situations, such as when children are under social stress or in rodents, when the new taste is presented in a high arousal context (HA) compared to a low arousal context (LA). The present study aimed at determining whether adrenergic transmission at the Insula regulates the reluctance to try novel tastes induced by arousing contexts. To this end, a combination of systemic and intra-insular manipulations of adrenergic activity was performed before the novel taste (saccharin 0.1%) was presented either in LA or HA contexts in rats. Our results show that systemic adrenergic activity modulates reluctance to try novel tastes. Moreover, intra-insular microinjections of propranolol or norepinephrine (NE) were found to modulate the effects of arousing contexts on reluctance to try novel tastes. Finally, intra-insular propranolol blocked epinephrine-induced increased reluctance, while intra-insular NE blocked oral propranolol-induced decreases in reluctance and increased the reluctance to try novel tastes presented in low arousing contexts. In conclusion, our results suggest that the insula is a critical site for regulating the effects of arousal in the reluctance to try novel tastes via the adrenergic system. © 2015 Rojas, Diaz-Galarce, Jerez-Baraona, Quintana-Donoso, Moraga-Amaro and Stehberg.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnbeh.2015.00164/full
dc.identifier.citationFrontiers in Behavioral Neuroscience Volume 9, Issue JUNE29 June 2015 Article number 164es
dc.identifier.doi10.3389/fnbeh.2015.00164
dc.identifier.issn1662-5153
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/49543
dc.language.isoenes
dc.publisherFrontiers Research Foundationes
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAdrenergic activityes
dc.subjectArousales
dc.subjectInsulaes
dc.subjectInsular cortexes
dc.subjectReluctancees
dc.subjectTaste neophobies
dc.titleThe insula modulates arousal-induced reluctance to try novel tastes through adrenergic transmission in the rates
dc.typeArtículoes
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