Heterogeneous contribution of microdeletions in the development of common generalised and focal epilepsies

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dc.contributor.authorPérez-Palma, Eduardo
dc.contributor.authorHelbig, Ingo
dc.contributor.authorKlein, Karl Martin
dc.contributor.authorAnttila, Verneri
dc.contributor.authorHorn, Heiko
dc.contributor.authorReinthaler, Eva Maria
dc.contributor.authorGormley, Padhraig
dc.contributor.authorGanna, Andrea
dc.contributor.authorByrnes, Andrea
dc.contributor.authorPernhorst, Katharina
dc.contributor.authorToliat, Mohammad R.
dc.contributor.authorSaarentaus, Elmo
dc.contributor.authorHowrigan, Daniel P.
dc.contributor.authorHoffman, Per
dc.contributor.authorMiquel, Juan Francisco
dc.contributor.authorDe Ferrari, Giancarlo V.
dc.contributor.authorNürnberg, Peter
dc.contributor.authorLerche, Holger
dc.contributor.authorZimprich, Fritz
dc.contributor.authorNeubauer, Bern A.
dc.contributor.authorBecker, Albert J.
dc.contributor.authorRosenow, Felix
dc.contributor.authorPerucca, Emilio
dc.contributor.authorZara, Federico
dc.contributor.authorWeber, Yvonne G.
dc.contributor.authorLal, Dennis
dc.date.accessioned2024-04-01T13:05:49Z
dc.date.available2024-04-01T13:05:49Z
dc.date.issued2017-09
dc.description.abstractBackground Microdeletions are known to confer risk to epilepsy, particularly at genomic rearrangement 'hotspot' loci. However, microdeletion burden not overlapping these regions or within different epilepsy subtypes has not been ascertained. Objective T o decipher the role of microdeletions outside hotspots loci and risk assessment by epilepsy subtype. Methods We assessed the burden, frequency and genomic content of rare, large microdeletions found in a previously published cohort of 1366 patients with genetic generalised epilepsy (GGE) in addition to two sets of additional unpublished genome-wide microdeletions found in 281 patients with rolandic epilepsy (RE) and 807 patients with adult focal epilepsy (AFE), totalling 2454 cases. Microdeletions were assessed in a combined and subtype-specific approaches against 6746 controls. Results When hotspots are considered, we detected an enrichment of microdeletions in the combined epilepsy analysis (adjusted p=1.06×10-6,OR 1.89, 95% CI 1.51 to 2.35). Epilepsy subtype-specific analyses showed that hotspot microdeletions in the GGE subgroup contribute most of the overall signal (adjusted p=9.79×10-12, OR 7.45, 95% CI 4.20-13.5). Outside hotspots , microdeletions were enriched in the GGE cohort for neurodevelopmental genes (adjusted p=9.13×10-3,OR 2.85, 95% CI 1.62-4.94). No additional signal was observed for RE and AFE. Still, gene-content analysis identified known (NRXN1, RBFOX1 and PCDH7) and novel (LOC102723362) candidate genes across epilepsy subtypes that were not deleted in controls. Conclusions Our results show a heterogeneous effect of recurrent and non-recurrent microdeletions as part of the genetic architecture of GGE and a minor contribution in the aetiology of RE and AFE. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017.
dc.description.urihttps://jmg-bmj-com.recursosbiblioteca.unab.cl/content/54/9/598
dc.identifier.citationJournal of Medical Genetics Volume 54, Issue 9, Pages 598 - 6061 September 2017
dc.identifier.doi10.1136/jmedgenet-2016-104495
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/55492
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.rights.licenseCC BY 4.0 DEED Atribución 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.titleHeterogeneous contribution of microdeletions in the development of common generalised and focal epilepsies
dc.typeArtículo
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