Gestational hypothyroidism improves the ability of the female offspring to clear streptococcus pneumoniae infection and to recover from pneumococcal pneumonia

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dc.contributor.authorNieto, Pamela A.
dc.contributor.authorPeñaloza, Hernán F.
dc.contributor.authorSalazar-Echegarai, Francisco J.
dc.contributor.authorCastellanos, Raquel M.
dc.contributor.authorOpazo, Maria Cecilia
dc.contributor.authorVenegas, Luis
dc.contributor.authorPadilla, Oslando
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorBueno, Susan M.
dc.date.accessioned2023-10-26T12:59:04Z
dc.date.available2023-10-26T12:59:04Z
dc.date.issued2016-06
dc.descriptionIndexación: Scopus.es
dc.description.abstractMaternal thyroid hormones are essential for proper fetal development. A deficit of these hormones during gestation has enduring consequences in the central nervous system of the offspring, including detrimental learning and impaired memory. Few studies have shown that thyroid hormone deficiency has a transient effect in the number of T and B cells in the offspring gestated under hypothyroidism; however, there are no studies showing whether maternal hypothyroidism during gestation impacts the response of the offspring to infections. In this study, we have evaluated whether adult mice gestated in hypothyroid mothers have an altered response to pneumococcal pneumonia. We observed that female mice gestated in hypothyroidism have increased survival rate and less bacterial dissemination to blood and brain after an intranasal challenge with Streptococcus pneumoniae. Further, these mice had higher amounts of inflammatory cells in the lungs and reduced production of cytokines characteristic of sepsis in spleen, blood, and brain at 48 hours after infection. Interestingly, mice gestated in hypothyroid mothers had basally increased vascular permeability in the lungs. These observations suggest that gestational hypothyroidism alters the immune response and the physiology of lungs in the offspring, increasing the resistance to respiratory bacterial infections.es
dc.description.urihttps://academic.oup.com/endo/article/157/6/2217/2422437?login=true
dc.identifier.citationEndocrinology. Volume 157, Issue 6, Pages 2217 - 2228. June 2016es
dc.identifier.doiDOI: 10.1210/en.2015-1957
dc.identifier.issn0013-7227
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/53639
dc.language.isoenes
dc.publisherEndocrine Societyes
dc.subjectEndocrinology and Diabeteses
dc.subjectClinical Medicinees
dc.subjectMedicine and Healthes
dc.subjectGestational Hypothyroidismes
dc.subjectPneumococcal Pneumoniaes
dc.titleGestational hypothyroidism improves the ability of the female offspring to clear streptococcus pneumoniae infection and to recover from pneumococcal pneumoniaes
dc.typeArtículoes
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