Relación neutrófilo a linfocito, recuento linfocitario e índices de actividad inflamatoria como factores pronóstico en infecciones por SARS-CoV-2: Un estudio de cohorte prospectiva

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dc.contributor.authorMartínez, Felipe
dc.contributor.authorBoisier, Dominique
dc.contributor.authorVergara, Constanza
dc.contributor.authorVidal, Jaime
dc.date.accessioned2024-11-20T15:52:19Z
dc.date.available2024-11-20T15:52:19Z
dc.date.issued2022
dc.descriptionIndexación: Scopus.
dc.description.abstractIntroduction: Patients with COVID-19 can develop respiratory failure requiring treatment with invasive mechanical ventilation (IMV) and death. It is important to have clinical predictors of these outcomes. Objetives: To establish the diagnostic accuracy of neutrophil to lymphocyte ratios (NLr) in predicting the need of IMV and survival amongst patients with COVID-19 and to compare this accuracy with other laboratory tests. Methodology: Prospective cohort study of hospitalized patients with a SArS-CoV-2 infection confirmed by rT-PCr. Clinical, demographic and laboratory predictors were assessed, including LDH, C-reactive protein, absolute lymphocyte counts, serum ferritin and NLr. Statistical analyses were undertaken using receiver-operator characteristics (rOC) curves, which were in turn compared using the method described by Hanley and McNeal. Results: One hundred and twelve patients were studied, most were male (60.7%) with a mean age of 63.4 ± 18.3 years. Twenty-two patients required IMV during their stay and 28 died. The NLr showed a good diagnostic accuracy in detecting patients that would require IMV (AUC 0.70, 95% CI 0.57-0.86) or died during the hospitalization (AUC 0.83, 95%CI 0.75-0.91). A cutoff point of 5.5 or higher had an 80.8% sensitivity and 73.1% specificity in detecting patients that died during their stay. Conclusions. NLr showed favorable diagnostic properties in detecting patients with COVID-19 at risk of adverse outcomes. Its wide availability and low cost are desirable features that might facilitate its implementation in routine clinical practice. © 2022 Sociedad de Anestesiologia de Chile. All rights reserved.
dc.description.urihttps://revistachilenadeanestesia.cl/revchilanestv5019071048/
dc.identifier.citationRevista Chilena de Anestesia, Volume 51, Issue 1, Pages 80 - 87, 2022
dc.identifier.doi10.25237/revchilanestv5019071048
dc.identifier.issn0716-4076
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/62082
dc.language.isoes
dc.publisherSociedad de Anestesiologia de Chile
dc.rights.licenseAttribution-NonCommercial 4.0 International CC BY-NC 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectCOVID-19
dc.subjectLymphocytes
dc.subjectMechanical ventilation
dc.subjectNeutrophils
dc.subjectPrognosis
dc.subjectSArS-CoV-2
dc.subjectSurvival
dc.titleRelación neutrófilo a linfocito, recuento linfocitario e índices de actividad inflamatoria como factores pronóstico en infecciones por SARS-CoV-2: Un estudio de cohorte prospectiva
dc.title.alternativeNeutrophil to lymphocite ratio and inflammatory biomarkers as prognostic factors amongst patients with COVID-19: A prospective cohort study
dc.typeArtículo
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